DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pisd and PSD1

DIOPT Version :9

Sequence 1:	NP_651208.1	Gene:	Pisd / 42849	FlyBaseID:	FBgn0026576	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_014230.1	Gene:	PSD1 / 855552	SGDID:	S000005113	Length:	500	Species:	Saccharomyces cerevisiae

Alignment Length:	521	Identity:	169/521 - (32%)
Similarity:	237/521 - (45%)	Gaps:	132/521 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LQLQPIKGPQPQAQN---ASLPVARHLRQFSSNP--ASKEAPLHHRRPQHK---QQPNPSQELAQ 87
            :.:.|:|....|.:.   ..:|..:    ||:..  .::.|.|.:|:...:   ||...|.|:..
Yeast     1 MSIMPVKNALAQGRTLLMGRMPAVK----FSTRMQLRNRTAVLWNRKFSTRLFVQQRRSSGEIVD 61

  Fly    88 I---------RRNILSRW---TGFLLRWAPMGICVFGAIEWQLQKNRCEKEGKPRTASELQSRI- 139
            .         |:.:..:|   |.|.:        |.|.|....:.:..|::...........:|
Yeast    62 RAKAAAANSGRKQVSMKWVVLTSFTI--------VLGTILLVSRNDSTEEDATEGKKGRRTRKIK 118

  Fly   140 ----------YCSLPLRIISRCWGWLAACYLPPSLRPYVYGWYSNTFDVNLSEAMYPEYEHYNSL 194
                      |.:|||..:||.||.:.:..||..:||:.|..||..|.|||.|...|:..||.:|
Yeast   119 IFNNNWLFFCYSTLPLNAMSRLWGQVNSLTLPIWVRPWGYRLYSFLFGVNLDEMEDPDLTHYANL 183

  Fly   195 AEFFTRPLKEGVRVIDQ-QAPLVSPADGKVLHFG--SASDSLIEQVKGVSYSIEDFLG----PL- 251
            :|||.|.:|.|.|.:.| :..:.||:|||:|..|  ::....||||||::|||::|||    ||
Yeast   184 SEFFYRNIKPGTRPVAQGEDVIASPSDGKILQVGIINSETGEIEQVKGMTYSIKEFLGTHSHPLM 248

  Fly   252 ------------------------------ETVEQ-----ANSGASYAQALKKK----------- 270
                                          |..||     .|.|....:..|..
Yeast   249 SKSASSLDLTSDEEKHREFARVNRIQLAGSEDTEQPLLNFKNEGDQSVREFKPSVSKNIHLLSQL 313

  Fly   271 -----SDG-------STELYQCVIYLAPGDYHRFHSPTAWKPTIRRHFSGELLSVSPKVAGWLPG 323
                 |:|       .|||:..||||||||||.||||..|...:||||.|:|.||:|......|.
Yeast   314 SLNYFSNGFSCSEPHDTELFFAVIYLAPGDYHHFHSPVDWVCKVRRHFPGDLFSVAPYFQRNFPN 378

  Fly   324 LFCLNERVLYMGQWKHGFFSYTAVGATNVGSVEIYMDADLKTNRWTGFNVGKH--PPSTYE--YD 384
            ||.|||||..:|.||:||||.|.||||||||:::..|.:..||.    ...||  |.:.|:  |:
Yeast   379 LFVLNERVALLGSWKYGFFSMTPVGATNVGSIKLNFDQEFVTNS----KSDKHLEPHTCYQAVYE 439

  Fly   385 ELVLNKELTEAPKEFG-----KGDLVGQFNMGSTIVLLFEAPKNFKFDIIAGQKIRVGESLGHIV 444
                     .|.|..|     ||:.:|.|.:|||:||.||||..||||:..|.|:::|:.|| |:
Yeast   440 ---------NASKILGGMPLVKGEEMGGFELGSTVVLCFEAPTEFKFDVRVGDKVKMGQKLG-II 494

  Fly   445 G 445
            |
Yeast   495 G 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pisd	NP_651208.1	PLN02938	61..441	CDD:178526	159/482 (33%)
Pisd	NP_651208.1	PS_Dcarbxylase	180..443	CDD:295959	127/337 (38%)
PSD1	NP_014230.1	PS_decarb	169..495	CDD:272936	128/339 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344873
Domainoid	1	1.000	209	1.000	Domainoid score	I515
eggNOG	1	0.900	-	-		E1_COG0688
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81653
Inparanoid	1	1.050	251	1.000	Inparanoid score	I662
Isobase	1	0.950	-	0	Normalized mean entropy	S2148
OMA	1	1.010	-	-		QHG53621
OrthoFinder	1	1.000	-	-		FOG0003152
OrthoInspector	1	1.000	-	-		oto99585
orthoMCL	1	0.900	-	-		OOG6_102081
Panther	1	1.100	-	-	LDO	PTHR10067
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1016
SonicParanoid	1	1.000	-	-		X2547
TreeFam	1	0.960	-	-
	16	15.740