DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pisd and pisd

DIOPT Version :9

Sequence 1:	NP_651208.1	Gene:	Pisd / 42849	FlyBaseID:	FBgn0026576	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_001073170.1	Gene:	pisd / 553433	ZFINID:	ZDB-GENE-061215-46	Length:	426	Species:	Danio rerio

Alignment Length:	430	Identity:	185/430 - (43%)
Similarity:	234/430 - (54%)	Gaps:	66/430 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QPIKGPQPQAQNASLPVARHLRQFSSNPASKEAP--LHHRRPQHKQQPNPSQELAQIRR----NI 92
            :|..|    |.||.          |..|.:...|  |.||.....|.|    :||..||    :.
Zfish    39 EPANG----AHNAG----------SGGPGAPGGPSQLSHRSRFRLQFP----QLALRRRLGQLSC 85

  Fly    93 LSRWTGFLLRWAPMG----ICVFGAIEWQLQKNRCEKEGKP------RTASELQSRIYCSLPLRI 147
            :||.|..|..| |:.    |..|||:             ||      |..|.:  .||.::|.|:
Zfish    86 MSRPTARLRSW-PLSFLYYILPFGAL-------------KPLAKVGWRPTSRV--TIYKTIPTRL 134

  Fly   148 ISRCWGWLAACYLPPSLRPYVYGWYSNTFDVNLSEAMYPEYEHYNSLAEFFTRPLKEGVRVIDQQ 212
            :||.||.|....||..||..:|..|..||.||:.||...:.:||.:|.|||.|.||..||.:...
Zfish   135 LSRAWGRLNRVDLPNWLRKPIYNLYIWTFGVNMKEAAVEDLQHYRNLGEFFRRKLKPQVRPVCDS 199

  Fly   213 APLVSPADGKVLHFGSASDSLIEQVKGVSYSIEDFLGP------LETVEQANSGASYAQALKKKS 271
            ..::||||||:||||...:..:||||||:||:|.||||      |......:...::..||..|.
Zfish   200 HCVISPADGKILHFGRVKNCEVEQVKGVTYSLETFLGPRTWSESLTANRNEDDPGTFQDALVTKE 264

  Fly   272 DGSTELYQCVIYLAPGDYHRFHSPTAWKPTIRRHFSGELLSVSPKVAGWLPGLFCLNERVLYMGQ 336
              ..||:.|||||||||||.|||||.|:...||||.|.|:||:|.||.|:..|||.||||:..|:
Zfish   265 --GNELFHCVIYLAPGDYHCFHSPTDWRVAHRRHFPGALMSVNPGVARWIKELFCHNERVVLSGE 327

  Fly   337 WKHGFFSYTAVGATNVGSVEIYMDADLKTNRWTGFNVGKHPPSTYEYDELVLNKELTEAPKEFGK 401
            |.|||||.||||||||||:.||.|.:|:||. ..:|.|     ||.....|.|.  .:......|
Zfish   328 WTHGFFSLTAVGATNVGSIRIYFDKELRTNN-PRYNKG-----TYNDFSYVTNN--NQEGISMRK 384

  Fly   402 GDLVGQFNMGSTIVLLFEAPKNFKFDIIAGQKIRVGESLG 441
            |:.:|:||:|||||||||||::|.|::.||||||.||:||
Zfish   385 GEHLGEFNLGSTIVLLFEAPRDFTFNLQAGQKIRFGEALG 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pisd	NP_651208.1	PLN02938	61..441	CDD:178526	177/401 (44%)
Pisd	NP_651208.1	PS_Dcarbxylase	180..443	CDD:295959	135/268 (50%)
pisd	NP_001073170.1	PLN02964	120..424	CDD:332215	153/315 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587268
Domainoid	1	1.000	240	1.000	Domainoid score	I2223
eggNOG	1	0.900	-	-		E1_COG0688
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81653
Inparanoid	1	1.050	284	1.000	Inparanoid score	I2843
OMA	1	1.010	-	-		QHG53621
OrthoDB	1	1.010	-	-		D1226492at2759
OrthoFinder	1	1.000	-	-		FOG0003152
OrthoInspector	1	1.000	-	-		oto41362
orthoMCL	1	0.900	-	-		OOG6_102081
Panther	1	1.100	-	-	LDO	PTHR10067
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1016
SonicParanoid	1	1.000	-	-		X2547
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800