DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pisd and Pisd

DIOPT Version :9

Sequence 1:	NP_651208.1	Gene:	Pisd / 42849	FlyBaseID:	FBgn0026576	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	XP_036021116.1	Gene:	Pisd / 320951	MGIID:	2445114	Length:	436	Species:	Mus musculus

Alignment Length:	415	Identity:	176/415 - (42%)
Similarity:	221/415 - (53%)	Gaps:	82/415 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LPVARHLRQFS--SNPASKEAP-----LHHRRPQHKQQPNPSQELAQIRRNILSRWTGFLLRWAP 105
            |.:.|.|.|.|  |.||.|...     ||:..|.....|     |:|:             .|.|
Mouse    85 LALRRRLGQLSCMSRPALKLRSWPLTILHYLLPFRALGP-----LSQV-------------GWRP 131

  Fly   106 MGICVFGAIEWQLQKNRCEKEGKPRTASELQSRI--YCSLPLRIISRCWGWLAACYLPPSLRPYV 168
            |                              ||:  |.|:|.|::||..|.|....||..||..|
Mouse   132 M------------------------------SRVSLYKSVPTRLLSRACGRLNQVELPYWLRRPV 166

  Fly   169 YGWYSNTFDVNLSEAMYPEYEHYNSLAEFFTRPLKEGVRVIDQQAPLVSPADGKVLHFGSASDSL 233
            |..|..||.||::||...:..||.:|:|||.|.||...|.:.....:.||:|||:|.||...:|.
Mouse   167 YSLYIWTFGVNMTEAAVEDLHHYRNLSEFFRRKLKPQARPVCGLHCVTSPSDGKILTFGQVKNSE 231

  Fly   234 IEQVKGVSYSIEDFLGPLETVEQ-----ANSGASYAQALKKKSDGSTELYQCVIYLAPGDYHRFH 293
            :||||||:||:|.||||....|.     |:|..|:...|..:.  ..|||.|||||||||||.||
Mouse   232 VEQVKGVTYSLESFLGPRANTEDLPFPPASSSDSFRNQLVTRE--GNELYHCVIYLAPGDYHCFH 294

  Fly   294 SPTAWKPTIRRHFSGELLSVSPKVAGWLPGLFCLNERVLYMGQWKHGFFSYTAVGATNVGSVEIY 358
            |||.|..:.||||.|.|:||:|.:|.|:..|||.||||:..|.|||||||.||||||||||:.|:
Mouse   295 SPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIH 359

  Fly   359 MDADLKTN--RWTGFNVGKHPPSTYEYDELVLNKELTEAPKE---FGKGDLVGQFNMGSTIVLLF 418
            .|.||.||  |:          |...|::|..   :|.|.||   ..||:.:|:||:||||||:|
Mouse   360 FDRDLHTNSPRY----------SKGSYNDLSF---VTHANKEGIPMRKGEPLGEFNLGSTIVLIF 411

  Fly   419 EAPKNFKFDIIAGQKIRVGESLGHI 443
            ||||:|.|.:.||||||.||:||.:
Mouse   412 EAPKDFNFRLKAGQKIRFGEALGSL 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pisd	NP_651208.1	PLN02938	61..441	CDD:178526	168/396 (42%)
Pisd	NP_651208.1	PS_Dcarbxylase	180..443	CDD:295959	137/272 (50%)
Pisd	XP_036021116.1	PLN02938	131..434	CDD:178526	131/311 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842820
Domainoid	1	1.000	236	1.000	Domainoid score	I2339
eggNOG	1	0.900	-	-		E1_COG0688
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81653
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2869
Isobase	1	0.950	-	0	Normalized mean entropy	S2148
OMA	1	1.010	-	-		QHG53621
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003152
OrthoInspector	1	1.000	-	-		oto93479
orthoMCL	1	0.900	-	-		OOG6_102081
Panther	1	1.100	-	-	LDO	PTHR10067
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1016
SonicParanoid	1	1.000	-	-		X2547
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740