DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pisd and PISD

DIOPT Version :9

Sequence 1:	NP_651208.1	Gene:	Pisd / 42849	FlyBaseID:	FBgn0026576	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_001313340.1	Gene:	PISD / 23761	HGNCID:	8999	Length:	409	Species:	Homo sapiens

Alignment Length:	360	Identity:	166/360 - (46%)
Similarity:	211/360 - (58%)	Gaps:	23/360 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 TGFLLRWAPMGICVFGAIEW--QLQKNR---CEKEG---KPRTASELQSRIYCSLPLRIISRCWG 153
            |.||||..|:.:...|....  |.:|.|   .||.|   .|:.|...:..:|.|:|.|::||.||
Human    60 TMFLLRPLPILLVTGGGYAGYRQYEKYRERELEKLGLEIPPKLAGHWEVALYKSVPTRLLSRAWG 124

  Fly   154 WLAACYLPPSLRPYVYGWYSNTFDVNLSEAMYPEYEHYNSLAEFFTRPLKEGVRVIDQQAPLVSP 218
            .|....||..||..||..|..||.||:.||...:..||.:|:|||.|.||...|.:.....::||
Human   125 RLNQVELPHWLRRPVYSLYIWTFGVNMKEAAVEDLHHYRNLSEFFRRKLKPQARPVCGLHSVISP 189

  Fly   219 ADGKVLHFGSASDSLIEQVKGVSYSIEDFLGPLETVEQ-----ANSGASYAQALKKKSDGSTELY 278
            :||::|:||...:..:||||||:||:|.||||....|.     |.|..|:...|..:.  ..|||
Human   190 SDGRILNFGQVKNCEVEQVKGVTYSLESFLGPRMCTEDLPFPPAASCDSFKNQLVTRE--GNELY 252

  Fly   279 QCVIYLAPGDYHRFHSPTAWKPTIRRHFSGELLSVSPKVAGWLPGLFCLNERVLYMGQWKHGFFS 343
            .|||||||||||.|||||.|..:.||||.|.|:||:|.:|.|:..|||.||||:..|.|||||||
Human   253 HCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFS 317

  Fly   344 YTAVGATNVGSVEIYMDADLKTNRWTGFNVGKHPPSTYEYDELVLNKELTEAPKEFGKGDLVGQF 408
            .||||||||||:.||.|.||.||.      .:|...:|.....|.:......|..  ||:.:|:|
Human   318 LTAVGATNVGSIRIYFDRDLHTNS------PRHSKGSYNDFSFVTHTNREGVPMR--KGEHLGEF 374

  Fly   409 NMGSTIVLLFEAPKNFKFDIIAGQKIRVGESLGHI 443
            |:||||||:|||||:|.|.:..|||||.||:||.:
Human   375 NLGSTIVLIFEAPKDFNFQLKTGQKIRFGEALGSL 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pisd	NP_651208.1	PLN02938	61..441	CDD:178526	164/356 (46%)
Pisd	NP_651208.1	PS_Dcarbxylase	180..443	CDD:295959	131/267 (49%)
PISD	NP_001313340.1	PS_Dcarbxylase	151..407	CDD:295959	129/265 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152769
Domainoid	1	1.000	237	1.000	Domainoid score	I2336
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81653
Inparanoid	1	1.050	285	1.000	Inparanoid score	I2858
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53621
OrthoDB	1	1.010	-	-		D1226492at2759
OrthoFinder	1	1.000	-	-		FOG0003152
OrthoInspector	1	1.000	-	-		oto89902
orthoMCL	1	0.900	-	-		OOG6_102081
Panther	1	1.100	-	-	LDO	PTHR10067
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1016
SonicParanoid	1	1.000	-	-		X2547
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940