DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rox8 and NPL3

DIOPT Version :9

Sequence 1:	NP_001262897.1	Gene:	Rox8 / 42848	FlyBaseID:	FBgn0005649	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_010720.3	Gene:	NPL3 / 852042	SGDID:	S000002840	Length:	414	Species:	Saccharomyces cerevisiae

Alignment Length:	222	Identity:	50/222 - (22%)
Similarity:	85/222 - (38%)	Gaps:	60/222 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LYVGNLDSSVSEDLLIALFSTMGPVKSCKIIREPGNDPYAFIEYSNYQAATTALTAMNKRLFLEK 73
            |:|......|.|..|..:|...||:|..||:     :.:||:|:...::|..|:..::.:.|..:
Yeast   127 LFVRPFPLDVQESELNEIFGPFGPMKEVKIL-----NGFAFVEFEEAESAAKAIEEVHGKSFANQ 186

  Fly    74 EIKVNWATSPG--------NQPK----TDISSHHHIFVGDLSPEIETETLREAFAPFGEISNCRI 126
            .::|.::..|.        |.|:    .|:.        ||:.|...||      .|..:
Yeast   187 PLEVVYSKLPAKRYRITMKNLPEGCSWQDLK--------DLARENSLET------TFSSV----- 232

  Fly   127 VRDPHTMKSKGYAFVSFVKKAEAENAIQAMNG-QWIGSRSIRTNWSTRKLPPPREPSKGG--GQG 188
                :|....|...:.|..:.....|::.:|. ::.|  |:.|.......||.|..::||  |:|
Yeast   233 ----NTRDFDGTGALEFPSEEILVEALERLNNIEFRG--SVITVERDDNPPPIRRSNRGGFRGRG 291

  Fly   189 GGMG---------------GGPGNGSG 200
            |..|               |||..|.|
Yeast   292 GFRGGFRGGFRGGFSRGGFGGPRGGFG 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rox8	NP_001262897.1	ELAV_HUD_SF	5..274	CDD:273741	50/222 (23%)
		RRM1_TIA1_like	9..80	CDD:240798	18/70 (26%)
		RRM2_TIA1_like	96..170	CDD:240799	14/74 (19%)
		RRM3_TIA1_like	221..294	CDD:240800
NPL3	NP_010720.3	PHA03247	<11..87	CDD:223021
		RBD_RRM1_NPL3	126..192	CDD:409777	18/69 (26%)
		RRM2_SRSF1_4_like	200..271	CDD:409776	17/95 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900