Protein Alignment Rox8 and TIA1

DIOPT Version :9

• Sequence 1: NP_001262897.1
• Gene: Rox8 / 42848
• FlyBaseID: FBgn0005649
• Length: 470
• Species: Drosophila melanogaster
• Sequence 2: NP_071505.2
• Gene: TIA1 / 7072
• HGNCID: 11802
• Length: 386
• Species: Homo sapiens
• Alignment Length: 483
• Identity: 181/483 - (37%)
• Similarity: 242/483 - (50%)
• Gaps: 110/483 - (22%)

  Fly     1 MDESQPKTLYVGNLDSSVSEDLLIALFSTMGPVKSCKIIRE-PGNDPYAFIEYSNYQAATTALTA 64
            |::..|||||||||...|:|.|::.|||.:||.|:||:|.: .|||||.|:|:..::.|..||.|
Human     1 MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAAAALAA 65

  Fly    65 MNKRLFLEKEIKVNWATSPGNQPKTDISS----------HHHIFVGDLSPEIETETLREAFAPFG 119
            ||.|..:.||:||||||:|.:|.|...||          |.|:|||||||||.||.::.||||||
Human    66 MNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHFHVFVGDLSPEITTEDIKAAFAPFG 130

  Fly   120 EISNCRIVRDPHTMKSKGYAFVSFVKKAEAENAIQAMNGQWIGSRSIRTNWSTRKLPPPREPSKG 184
            .||:.|:|:|..|.|||||.||||..|.:||||||.|.|||:|.|.|||||:|||.|.|:...:
Human   131 RISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYE- 194

  Fly   185 GGQGGGMGGGPGNGSGVKGSQRHTFEEVYNQSSPTNTTVYCGGFPPNVISDDLMHKHFVQFGPIQ 249
                             ..:::.:::||.|||||:|.||||||.... :::.||.:.|..||.|.
Human   195 -----------------SNTKQLSYDEVVNQSSPSNCTVYCGGVTSG-LTEQLMRQTFSPFGQIM 241

  Fly   250 DVRVFKDKGFSFIKFVTKEAAAHAIEHTHNSEVHGNLVKCFWGKENGGDNSANNLNAAAAAAAAS 314
            ::|||.|||:||::|.:.|:|||||...:.:.:.|::|||:||||.
Human   242 EIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKET------------------- 287

  Fly   315 ANVAAVAAANAAVAAGAGMPGQMMTQQQIAAATGAAIPGQMMTPQQIAAQYPYAYQQMGYWYPPA 379
                            ..|...:..|.||.                    ||..|.|.|.||..|
Human   288 ----------------LDMINPVQQQNQIG--------------------YPQPYGQWGQWYGNA 316

  Fly   380 TYPTTQMQTQYMQQGYYPYAYPTSAQQAGGVPCIQFSAAGYRMVPPNVAWGVP--GTVVPGVTAA 442
                 |...|||..|:...||....|        .::..|:.....:..|..|  |...|
Human   317 -----QQIGQYMPNGWQVPAYGMYGQ--------AWNQQGFNQTQSSAPWMGPNYGVQPP----- 363

  Fly   443 AASAAAAANGSLAPQMMYSAAMPQYQTQ 470
                 ...|||:.|.......:..|:||
Human   364 -----QGQNGSMLPNQPSGYRVAGYETQ 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rox8	NP_001262897.1	ELAV_HUD_SF	5..274	CDD:273741	138/279 (49%)
		RRM1_TIA1_like	9..80	CDD:240798	37/71 (52%)
		RRM2_TIA1_like	96..170	CDD:240799	49/73 (67%)
		RRM3_TIA1_like	221..294	CDD:240800	33/72 (46%)
TIA1	NP_071505.2	RRM1_TIA1	8..81	CDD:410027	38/72 (53%)
		RRM2_TIA1	104..181	CDD:410030	50/76 (66%)
		RRM3_TIAR	214..286	CDD:241064	33/72 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..386		8/41 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7073
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	305	1.000	Inparanoid score	I2646
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1066369at2759
OrthoFinder	1	1.000	-	-		FOG0000924
OrthoInspector	1	1.000	-	-		otm40404
orthoMCL	1	0.900	-	-		OOG6_103013
Panther	1	1.100	-	-	O	PTHR10352
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1842
SonicParanoid	1	1.000	-	-		X831
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860