Protein Alignment Rox8 and SNRNP70

DIOPT Version :10

• Sequence 1: NP_732944.2
• Gene: Rox8 / 42848
• FlyBaseID: FBgn0005649
• Length: 470
• Species: Drosophila melanogaster
• Sequence 2: NP_003080.2
• Gene: SNRNP70 / 6625
• HGNCID: 11150
• Length: 437
• Species: Homo sapiens
• Alignment Length: 220
• Identity: 52/220 - (23%)
• Similarity: 87/220 - (39%)
• Gaps: 51/220 - (23%)

  Fly    23 LIALFSTMGPVKSC----KIIREP-GNDPYAFI-----EYSNYQAATTALTAMNKRLFLEK---- 73
            |:|||:...|:...    |:..|. .|.||..|     |:.:.:.|.....|..:...:|:
Human     9 LLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRRE 73

  Fly    74 -----------EIKVNWATSPGNQPKTDISSHHHIFVGDLSPEIETETLREAFAPFGEISNCRIV 127
                       |:|: |  .|.|.|.....:...:||..::.:.....||..|..:|.|....:|
Human    74 KIERRQQEVETELKM-W--DPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMV 135

  Fly   128 RDPHTMKSKGYAFVSFVKKAEAENAIQAMNGQWIGSRSI-------RT--NWSTRKLPPPREPSK 183
            ....:.|.:||||:.:..:.:..:|.:..:|:.|..|.:       ||  .|..|:|
Human   136 YSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRL-------- 192

  Fly   184 GGGQGGGMGGGPGNGSGVKGSQRHT 208
                |||:||....|:.|  :.||:
Human   193 ----GGGLGGTRRGGADV--NIRHS 211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rox8	NP_732944.2	RRM1_TIA1_like	9..80	CDD:409788	17/81 (21%)
		RRM2_TIA1_like	96..170	CDD:409789	19/82 (23%)
		RRM_SF	221..292	CDD:473069
SNRNP70	NP_003080.2	U1snRNP70_N	3..94	CDD:432406	19/87 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..79		3/30 (10%)
		Required for interaction with U1 RNA. /evidence=ECO:0000269|PubMed:2467746	92..202		29/121 (24%)
		RRM_snRNP70	102..187	CDD:409682	19/84 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	187..437		12/39 (31%)