DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rox8 and SRSF4

DIOPT Version :9

Sequence 1:	NP_001262897.1	Gene:	Rox8 / 42848	FlyBaseID:	FBgn0005649	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_005617.2	Gene:	SRSF4 / 6429	HGNCID:	10786	Length:	494	Species:	Homo sapiens

Alignment Length:	202	Identity:	44/202 - (21%)
Similarity:	77/202 - (38%)	Gaps:	44/202 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 IFVGDLSPEIETETLREAFAPFGEISNCRIVRDPHTMKSKGYAFVSFVKKAEAENAIQAMNGQWI 161
            :::|.||.:.....:...|..:|:|....:        ..||.||.|....:|::|:..:||:.:
Human     4 VYIGRLSYQARERDVERFFKGYGKILEVDL--------KNGYGFVEFDDLRDADDAVYELNGKDL 60

  Fly   162 -GSRSIRTNWSTRKLPPPREPSKGGGQGGGMGGGPGNGSGVKGSQRHTFEEVYNQSSPTNTTVYC 225
             |.|.|        :...|.|.:.|..|.|.     :|.|.:.|.|..:       .|...|.|
Human    61 CGERVI--------VEHARGPRRDGSYGSGR-----SGYGYRRSGRDKY-------GPPTRTEY- 104

  Fly   226 GGFPPNVISDDL--------MHKHFVQFGPIQDVRVFKD-KGFSFIKFVTKEAAAHAIEHTHNSE 281
                 .:|.::|        :..:..|.|.:......|. |....|:||:......|:|....:|
Human   105 -----RLIVENLSSRCSWQDLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTE 164

  Fly   282 VHGNLVK 288
            |:|..::
Human   165 VNGRKIR 171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rox8	NP_001262897.1	ELAV_HUD_SF	5..274	CDD:273741	39/186 (21%)
		RRM1_TIA1_like	9..80	CDD:240798
		RRM2_TIA1_like	96..170	CDD:240799	18/73 (25%)
		RRM3_TIA1_like	221..294	CDD:240800	16/77 (21%)
SRSF4	NP_005617.2	RRM1_SRSF4_like	3..72	CDD:240783	18/83 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..95		8/27 (30%)
		RRM2_SRSF4_like	104..175	CDD:241044	15/74 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..494		0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810