DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rox8 and cstf2

DIOPT Version :9

Sequence 1:	NP_001262897.1	Gene:	Rox8 / 42848	FlyBaseID:	FBgn0005649	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	XP_009289373.1	Gene:	cstf2 / 386806	ZFINID:	ZDB-GENE-031118-2	Length:	508	Species:	Danio rerio

Alignment Length:	432	Identity:	97/432 - (22%)
Similarity:	151/432 - (34%)	Gaps:	112/432 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 ATSPGNQPKTDISSHHHIFVGDLSPEIETETLREAFAPFGEISNCRIVRDPHTMKSKGYAFVSFV 144
            |.:....|..| .|...:|||::..|...|.|::.|:..|.:.:.|:|.|..|.|.|||.|..:.
Zfish    10 AAAAARDPAVD-RSLRSVFVGNIPYEATEEQLKDIFSEVGLVVSFRLVYDRETGKPKGYGFCEYQ 73

  Fly   145 KKAEAENAIQAMNGQWIGSRSIRT-NWSTRKLPPPREPSKGGGQGGGMGGGP-GNGSGVKGSQRH 207
            .:..|.:|::.:||:....|::|. |.::.|   .:|..|..|.|..:...| |:|
Zfish    74 DQETALSAMRNLNGREFSGRALRVDNAASEK---NKEELKSLGTGAPIIESPYGDG--------- 126

  Fly   208 TFEEVYNQSSPTNTTVYCGGFPPNVISDDLMH--KHFVQFGPIQDVR--VFKDKGFSF------- 261
                ...:.:|.:.:......||..:. :||.  |..||..| |:.|  :.::...::
Zfish   127 ----CMPEEAPESISRAVASLPPEQMF-ELMKQMKLCVQNSP-QEARNMLLQNPQLAYALLQAQV 185

  Fly   262 -IKFVTKEAAAHAIEHTHNSEVHGNLVKCFWGKENGGDNSANNLNAAAAAAAASANVAAVAAANA 325
             ::.|..|.   |::..|...|                  ...:|.:....|..|....:...|.
Zfish   186 VMRIVDPEI---ALKMLHRPAV------------------VPPINPSPQPGAVPAPNQPLPQPNV 229

  Fly   326 AVAAGAGMPG-------QMMTQQQIAAATGAAIPGQMMTPQQIAAQYPYAYQQMGYWYPPATYPT 383
            .|:....|||       |||...|:    |..:||.|      ..|.|     ||        |.
Zfish   230 PVSQPQPMPGLHVNGAPQMMQPPQM----GGGVPGPM------PGQGP-----MG--------PA 271

  Fly   384 TQMQTQY---------MQQGYYPYAYPTSAQQAGGVPCIQFSAA----------GYRMVPPNVAW 429
            ..||.|.         |.:|  |.....|...|.|...|:.|..          |....||
Zfish   272 GGMQPQIGIPPGGPVPMDRG--PGNLQDSPVGAAGQAAIERSQVPIVDPRAPMRGAPQGPP---- 330

  Fly   430 GVP--GTVVPGVTAAAASAAAAANGSLA-PQMMYSAAMPQYQ 468
            |:|  |.:..|.......:..:..|.:. |...|....||:|
Zfish   331 GIPPRGLLGDGPNDPRGGSLVSVTGEVVEPGRGYIGGPPQHQ 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rox8	NP_001262897.1	ELAV_HUD_SF	5..274	CDD:273741	49/207 (24%)
		RRM1_TIA1_like	9..80	CDD:240798	97/432 (22%)
		RRM2_TIA1_like	96..170	CDD:240799	23/74 (31%)
		RRM3_TIA1_like	221..294	CDD:240800	15/84 (18%)
cstf2	XP_009289373.1	RRM	<24..>112	CDD:223796	27/90 (30%)
		RRM_CSTF2_CSTF2T	26..100	CDD:241115	23/73 (32%)
		CSTF2_hinge	121..199	CDD:291025	17/95 (18%)
		CSTF_C	464..504	CDD:291002
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900