Protein Alignment Rox8 and Tial1

DIOPT Version :10

• Sequence 1: NP_732944.2
• Gene: Rox8 / 42848
• FlyBaseID: FBgn0005649
• Length: 470
• Species: Drosophila melanogaster
• Sequence 2: NP_001013211.1
• Gene: Tial1 / 361655
• RGDID: 1595845
• Length: 392
• Species: Rattus norvegicus
• Alignment Length: 472
• Identity: 181/472 - (38%)
• Similarity: 235/472 - (49%)
• Gaps: 112/472 - (23%)

  Fly     2 DESQPKTLYVGNLDSSVSEDLLIALFSTMGPVKSCKIIRE------------------PGNDPYA 48
            |:.||:|||||||...|:|.|::.|||.:||.||||:|.|                  ..||||.
  Rat     4 DDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQHTSNDPYC 68

  Fly    49 FIEYSNYQAATTALTAMNKRLFLEKEIKVNWATSPGNQPKTDISSHHHIFVGDLSPEIETETLRE 113
            |:|:..::.|..||.|||.|..|.||:||||||:|.:| |.|.|:|.|:|||||||||.||.::.
  Rat    69 FVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQ-KKDTSNHFHVFVGDLSPEITTEDIKS 132

  Fly   114 AFAPFGEISNCRIVRDPHTMKSKGYAFVSFVKKAEAENAIQAMNGQWIGSRSIRTNWSTRKLPPP 178
            ||||||:||:.|:|:|..|.|||||.||||..|.:|||||..|.|||:|.|.|||||:|||.|.|
  Rat   133 AFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAP 197

  Fly   179 REPSKGGGQGGGMGGGPGNGSGVKGSQRHTFEEVYNQSSPTNTTVYCGGFPPNVISDDLMHKHFV 243
            :...:                  ..:::..||:|.|||||.|.||||||.... ::|.||.:.|.
  Rat   198 KSTQE------------------TNTKQLRFEDVVNQSSPKNCTVYCGGIASG-LTDQLMRQTFS 243

  Fly   244 QFGPIQDVRVFKDKGFSFIKFVTKEAAAHAIEHTHNSEVHGNLVKCFWGKENGGDNSANNLNAAA 308
            .||.|.::|||.:||:||::|.|.|:|||||...:.:.:.|::|||:||||:
  Rat   244 PFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKES------------- 295

  Fly   309 AAAAASANVAAVAAANAAVAAGAGMPGQMMTQQQIAAATGAAIPGQMMTPQQIAAQYPYAYQQMG 373
                                     |......||:                        .|.|.|
  Rat   296 -------------------------PDMTKNFQQV------------------------DYSQWG 311

  Fly   374 YWYPPATYPTTQMQTQYMQQG-----YYPYAYPTSAQQAGGVPCIQFSA--AGYRMVPPNVAWGV 431
            .|  ...|...|...|||..|     |..|..|.: ||..||.....:|  .|:...||.  ...
  Rat   312 QW--SQVYGNPQQYGQYMANGWQVPPYGVYGQPWN-QQGFGVDQSPSAAWMGGFGAQPPQ--GQA 371

  Fly   432 PGTVVPGVTAAAASAAA 448
            |..|:|....|....|:
  Rat   372 PPPVIPPPNQAGYGMAS 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rox8	NP_732944.2	RRM1_TIA1_like	9..80	CDD:409788	39/88 (44%)
		RRM2_TIA1_like	96..170	CDD:409789	48/73 (66%)
		RRM_SF	221..292	CDD:473069	32/70 (46%)
Tial1	NP_001013211.1	RRM1_TIAR	10..107	CDD:410028	45/97 (46%)
		RRM2_TIAR	113..192	CDD:410029	51/78 (65%)
		RRM3_TIAR	222..294	CDD:241064	34/72 (47%)