Protein Alignment Rox8 and A1CF

DIOPT Version :10

• Sequence 1: NP_732944.2
• Gene: Rox8 / 42848
• FlyBaseID: FBgn0005649
• Length: 470
• Species: Drosophila melanogaster
• Sequence 2: NP_001185748.1
• Gene: A1CF / 29974
• HGNCID: 24086
• Length: 602
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 103/509 - (20%)
• Similarity: 164/509 - (32%)
• Gaps: 158/509 - (31%)

  Fly     9 LYVGNLDSSVSEDLLIALFS--TMGPVKSCKIIREPG------NDPYAFIEYSNYQAATTALTAM 65
            |:||.:..:...:.:::...  |.|.|   .:|..|.      |..:||:||.:::||     ||
Human   146 LFVGGIPKTKKREEILSEMKKVTEGVV---DVIVYPSAADKTKNRGFAFVEYESHRAA-----AM 202

  Fly    66 NKRLFLEKEIK-------VNWATSPGNQPKTDISSHHHIFVGDLSPEIETETLREAFAPF--GEI 121
            .:|..|...|:       |:||.......:..:||...::|.:|......|.:.:.|...  |.:
Human   203 ARRKLLPGRIQLWGHGIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPGAV 267

  Fly   122 SNCRIVRDPHTMKSKGYAFVSFVKKAEAENAIQAMNGQWIGSRSIRTNWSTRKLPPPREPSKGGG 186
            ...:.:||        ||||.|..:.:|..|::|:||:.:....|..   |...|..::......
Human   268 ERVKKIRD--------YAFVHFSNREDAVEAMKALNGKVLDGSPIEV---TLAKPVDKDSYVRYT 321

  Fly   187 QGGGMGGGPGNGSGVKGSQRHTFEEVYNQSSPTNTTVYCGGFPPNVISDDLMHKHFVQFGPIQDV 251
            :|.|     |.|:.::|...::..:||:.     ||.|.|                   .|:
Human   322 RGTG-----GRGTMLQGEYTYSLGQVYDP-----TTTYLG-------------------APV--- 354

  Fly   252 RVFKDKGFSFIKFVTKEAAAHAIEHTHNSEVHGNLVKCFWGKENGGDNSANNLNAAAAAAAASAN 316
                        |...:..| ||...|.....|:|                 .|.|...|.:...
Human   355 ------------FYAPQTYA-AIPSLHFPATKGHL-----------------SNRAIIRAPSVRE 389

  Fly   317 VAAVAAANAAVAAGAGMPGQMMTQQQIAAATGAA-----------------IPGQMMTPQ----- 359
            :.......||...|.|..|.:       |.||..                 :||..:||.
Human   390 IYMNVPVGAAGVRGLGGRGYL-------AYTGLGRGYQVKGDKREDKLYDILPGMELTPMNPVTL 447

  Fly   360 -----QIAAQYPYAYQQMGYWYPPATYPTTQMQTQYMQQGYYPYAYPTSAQQAGGVPCIQFSAAG 419
                 ::|.|......|...|..|.....:.:.....|...|....|..|.|         :.|.
Human   448 KPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKITIPALASQ---------NPAI 503

  Fly   420 YRMVPPNVA-----------------WGVPGTVVPGVTAAAASAAAAANGSLAP 456
            :...||.::                 .|:|.....|..|.||:||.|..|...|
Human   504 HPFTPPKLSAFVDEAKTYAAEYTLQTLGIPTDGGDGTMATAAAAATAFPGYAVP 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rox8	NP_732944.2	RRM1_TIA1_like	9..80	CDD:409788	21/85 (25%)
		RRM2_TIA1_like	96..170	CDD:409789	18/75 (24%)
		RRM_SF	221..292	CDD:473069	12/70 (17%)
A1CF	NP_001185748.1	hnRNP-R-Q	29..602	CDD:273732	103/509 (20%)