DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rox8 and mug24

DIOPT Version :9

Sequence 1:	NP_001262897.1	Gene:	Rox8 / 42848	FlyBaseID:	FBgn0005649	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_588373.1	Gene:	mug24 / 2539486	PomBaseID:	SPCC74.09	Length:	654	Species:	Schizosaccharomyces pombe

Alignment Length:	506	Identity:	101/506 - (19%)
Similarity:	171/506 - (33%)	Gaps:	170/506 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KTLYVGNL--DSSVSEDLLIALFSTMGPVKSCKIIREPG---------NDPYAFIEYSNYQAATT 60
            :.|.:|||  |..:||  |::|..: ||::  ||...||         :...||..|..|..
pombe   208 RALILGNLPVDYKISE--LLSLIHS-GPLE--KIQSNPGKRRIIITFLDSADAFFFYERYHP--- 264

  Fly    61 ALTAMNKRLFLEKEIKVNWATSPGNQPK------TDISSHHHIFVGDLSPEIETETLREAFAPFG 119
                 ...:|..:.:|:.:| .|...|:      ::.::..::|:|:|......:.:.|||..||
pombe   265 -----RGFIFHGRPLKLTFA-RPSPLPESIQNFCSNTAASRNVFIGNLPSSYHEKEIEEAFGKFG 323

  Fly   120 EISNCRIVRDPHTMKSKGYAFVSFVKKAEAENAIQAMN-----GQW---IGSRSIRTNWSTRKLP 176
            :|.:.:|      :..|..|||.|:...:|...::.::     ..|   .||.....:      |
pombe   324 KIEHIKI------LSKKNIAFVHFLNIRDAIKVVRTLSCDPDYHSWRIFFGSDRCANH------P 376

  Fly   177 PPREPSKGGGQGGGMGGGPGNGSGVKGSQRHTFEEVYNQSSPT------------NTTVYCGGFP 229
            |..:                        :|..|....|..:.:            |.||:.|...
pombe   377 PSFD------------------------ERSCFTSKQNPDTTSDRCRQQESKDNGNRTVFLGNLH 417

  Fly   230 PNVISDDLMHKHFVQFGPIQDVRVFKDKGFSFIKFVTKEAAAHAIEHTHNSEV--HGNLVKCFWG 292
            ......::.  ..::.|.:||.....:|...|:.|:|..||....::....||  ||..:|..||
pombe   418 TKTKGHEIC--DLIRHGGLQDFHYIPEKHICFVTFITYSAANAFHDYLAEEEVLLHGRRIKVGWG 480

  Fly   293 KENG---------------------------------------GD-NSANNLNAAAAAAAASANV 317
            ||:|                                       |: .|...|...::...|..|:
pombe   481 KESGPLPRVLEDSILMGASRNVYFSHISDSLTTEELELILRQYGEIESIKYLKNRSSGFVAYTNI 545

  Fly   318 A-AVAAANAAVAAGAGMPGQMM------------TQQQIAAATGAAIPGQMMTP-QQIAA---QY 365
            : |:.|.|       |:|...:            .:|::..:...: |.|...| ||...   .|
pombe   546 SNAMKAVN-------GLPIHPLFKKSKIRYAPDRCEQELQKSKSNS-PIQQNVPLQQFITPPFSY 602

  Fly   366 PYAYQQMGYWYPPATYPTTQMQTQYMQQGYYPYAYPTSAQQAGGVPCIQFS 416
            |.||...   .||.:.|......||  |.:.|:.         .||...|:
pombe   603 PVAYCPA---IPPGSDPILNFGIQY--QPFIPFT---------AVPSFPFN 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rox8	NP_001262897.1	ELAV_HUD_SF	5..274	CDD:273741	61/303 (20%)
		RRM1_TIA1_like	9..80	CDD:240798	21/81 (26%)
		RRM2_TIA1_like	96..170	CDD:240799	19/81 (23%)
		RRM3_TIA1_like	221..294	CDD:240800	19/74 (26%)
mug24	NP_588373.1	RRM	179..433	CDD:223796	52/276 (19%)
		RRM1_3_MRN1	208..280	CDD:240707	22/85 (26%)
		RRM2_MRN1	296..373	CDD:240967	19/82 (23%)
		RRM3_MRN1	408..481	CDD:240965	19/74 (26%)
		RRM4_MRN1	497..575	CDD:240966	10/84 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910