DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rox8 and Cstf2

DIOPT Version :9

Sequence 1:	NP_001262897.1	Gene:	Rox8 / 42848	FlyBaseID:	FBgn0005649	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001345982.1	Gene:	Cstf2 / 108062	MGIID:	1343054	Length:	603	Species:	Mus musculus

Alignment Length:	426	Identity:	94/426 - (22%)
Similarity:	149/426 - (34%)	Gaps:	92/426 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PGNQPKTDISSHHHIFVGDLSPEIETETLREAFAPFGEISNCRIVRDPHTMKSKGYAFVSFVKKA 147
            |...|..| .|...:|||::..|...|.|::.|:..|.:.:.|:|.|..|.|.|||.|..:..:.
Mouse     5 PVRDPAVD-RSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQE 68

  Fly   148 EAENAIQAMNGQWIGSRSIRT-NWSTRKLPPPREPSKGGGQGGGMGGGPGNGSGVKGSQRHTFEE 211
            .|.:|::.:||:....|::|. |.::.|   .:|..|..|.|..:...|..            |.
Mouse    69 TALSAMRNLNGREFSGRALRVDNAASEK---NKEELKSLGTGAPVIESPYG------------ES 118

  Fly   212 VYNQSSPTNTTVYCGGFPPNVISDDLMH--KHFVQFGPIQDVR--VFKDKGFSF--------IKF 264
            :..:.:|.:.:......||..:. :||.  |..||..| |:.|  :.::...::        ::.
Mouse   119 ISPEDAPESISKAVASLPPEQMF-ELMKQMKLCVQNSP-QEARNMLLQNPQLAYALLQAQVVMRI 181

  Fly   265 VTKEAAAHAIEHTHN--SEVHGNLVKCFWGKENGGDN-SANNLNAAAAAAAASANVAAVAAANAA 326
            |..|.|...:....|  :.:.||...........|.| |.|..|..|..|   .::..:....|.
Mouse   182 VDPEIALKILHRQTNIPTLISGNPQPVHVAGPGSGPNVSMNQQNPQAPQA---QSLGGMHVNGAP 243

  Fly   327 VAAGAGMPGQMMTQQQIAAATGAAIPGQMMTPQQIAAQYPYAYQQMGYWYPPATYPTTQMQTQYM 391
            ....|.|||.:....|:|||.|...||.:.                         |...||.|..
Mouse   244 PMMQASMPGGVPAPVQMAAAVGGPGPGSLA-------------------------PAGVMQAQVG 283

  Fly   392 QQGYYPYAYPTSAQQAGGVPCIQFSAAGYR--------------MVPPNVAWGVPGTVVPGVTAA 442
            .||    |.|...::..|.  :|.|..|..              |:..:|....|..:|.|....
Mouse   284 MQG----AGPVPMERGQGT--LQHSPVGPAGPASIERVQGQRTWMIWASVRGSTPSLLVSGGLDG 342

  Fly   443 AASAAA----------AANGSLAPQMMYSAAMPQYQ 468
            .|...|          ...|.:.|:.......|.:|
Mouse   343 IAVCDAPNDPRGGTLMTVTGDVEPRAYLGPPPPPHQ 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rox8	NP_001262897.1	ELAV_HUD_SF	5..274	CDD:273741	49/203 (24%)
		RRM1_TIA1_like	9..80	CDD:240798
		RRM2_TIA1_like	96..170	CDD:240799	23/74 (31%)
		RRM3_TIA1_like	221..294	CDD:240800	16/86 (19%)
Cstf2	NP_001345982.1	RRM	<7..332	CDD:330708	84/376 (22%)
		RRM_CSTF2_CSTF2T	18..92	CDD:241115	23/73 (32%)
		CSTF2_hinge	113..191	CDD:316816	16/91 (18%)
		Rnc	<418..>475	CDD:330804
		CSTF_C	559..599	CDD:316795
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900