Protein Alignment Rox8 and RBM14-RBM4

DIOPT Version :10

• Sequence 1: NP_732944.2
• Gene: Rox8 / 42848
• FlyBaseID: FBgn0005649
• Length: 470
• Species: Drosophila melanogaster
• Sequence 2: NP_001185774.1
• Gene: RBM14-RBM4 / 100526737
• HGNCID: 38840
• Length: 339
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 84/408 - (20%)
• Similarity: 138/408 - (33%)
• Gaps: 121/408 - (29%)

  Fly     9 LYVGNLD-SSVSEDLLIALFSTMGPVKSCKIIREPGNDPYAFIEYSNYQAATTALTAMNKRLFLE 72
            ::|||:| :..:.:.|.|||:..|.|.||.::::     :||:.......|..|:.|::..
Human     3 IFVGNVDGADTTPEELAALFAPYGTVMSCAVMKQ-----FAFVHMRENAGALRAIEALHGH---- 58

  Fly    73 KEIKVNWATSPGNQPKTDIS-----SHHHIFVGDLSPEIETETLREAFAPFGEISNCRIVRDPHT 132
             |::      ||.....::|     :...||||::|....::.||..|...|.:..|.:|
Human    59 -ELR------PGRALVVEMSRPRPLNTWKIFVGNVSAACTSQELRSLFERRGRVIECDVV----- 111

  Fly   133 MKSKGYAFVSFVKKAEAENAIQAMNGQWIGSRSIRTNWSTRKLPPPREPSKGGGQGGGMGGGPGN 197
               ||                :.|:.|...|| :||           .|..|...|....|..|:
Human   112 ---KG----------------KRMHVQLSTSR-LRT-----------APGMGDQSGCYRCGKEGH 145

  Fly   198 GSGV----KGSQRHTFEEVYNQSSPTNTTVYCGGFPPNVISDDLMHKHFVQFGPIQ--------- 249
            .|..    :..:.....|.||:......|.|...:     .|.|.:.:  .:|.:.
Human   146 WSKECPIDRSGRVADLTEQYNEQYGAVRTPYTMSY-----GDSLYYNN--AYGALDAYYKRCRAA 203

  Fly   250 -----------DVRVFKDKGFSFIKFVTKEAAAHAIEHTHNSEVHGNLVKCFWGKENGGDNSANN 303
                       .|..:.::..|.:..|...|.|..:..|.......:|:.              .
Human   204 RSYEAVAAAAASVYNYAEQTLSQLPQVQNTAMASHLTSTSLDPYDRHLLP--------------T 254

  Fly   304 LNAAAAAAAASANVAAVAAANAA------------------VAAGAGMPGQMMTQQQIAAATGAA 350
            ..|||.||||:|..|||.||:.:                  |..|.|...:....|..|||..:.
Human   255 SGAAATAAAAAAAAAAVTAASTSYYGRDRSPLRRATAPVPTVGEGYGYGHESELSQASAAARNSL 319

  Fly   351 IPGQMMTPQQIAAQYPYA 368
            ........:|.|.:..|:
Human   320 YDMARYEREQYADRARYS 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rox8	NP_732944.2	RRM1_TIA1_like	9..80	CDD:409788	18/71 (25%)
		RRM2_TIA1_like	96..170	CDD:409789	19/73 (26%)
		RRM_SF	221..292	CDD:473069	12/90 (13%)
RBM14-RBM4	NP_001185774.1	RRM1_CoAA	1..71	CDD:410020	20/83 (24%)
		RRM_SF	79..>113	CDD:473069	11/41 (27%)
		PTZ00368	<120..>156	CDD:173561	10/47 (21%)
		ZnF_C2HC	136..151	CDD:197667	4/14 (29%)