Protein Alignment spas and VPS4B

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_004860.2
• Gene: VPS4B / 9525
• HGNCID: 10895
• Length: 444
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 162/559 - (28%)
• Similarity: 250/559 - (44%)
• Gaps: 164/559 - (29%)

  Fly   234 RRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNL 298
            ::|.:..|||.:  |:..|:.|.|::||:..::..   :.|..:..:||  ...|.:..|....|
Human     9 QKAIDLASKAAQ--EDKAGNYEEALQLYQHAVQYF---LHVVKYEAQGD--KAKQSIRAKCTEYL 66

  Fly   299 SMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKA 363
            ..|                      ||.||..::|.:|.::|:..|
Human    67 DRA----------------------EKLKEYLKNKEKKAQKPVKEG------------------- 90

  Fly   364 TTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSS 428
                ||:.:..|             .|.|.                                 ..
Human    91 ----QPSPADEK-------------GNDSD---------------------------------GE 105

  Fly   429 GRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQ 493
            |.:..|::                          :||...:...||.....|:|:|:||.:.||:
Human   106 GESDDPEK--------------------------KKLQNQLQGAIVIERPNVKWSDVAGLEGAKE 144

  Fly   494 ALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATEC-SATFLNISAASLTSKYV 557
            ||:|.||||...|.||||.|.|.:|:|||||||.||:.||:|||||. ::||.:||::.|.||::
Human   145 ALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWL 209

  Fly   558 GDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRI 622
            |:.||||:.||.:||..:||||||||:|||...||.:|.||:||:||||||:..|:  ..|.|.|
Human   210 GESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGV--GVDNDGI 272

  Fly   623 VVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYS 687
            :||.|||.|..||.|..|||.||:|:.||:...|..:....|....:.|.....|.|.:.|||||
Human   273 LVLGATNIPWVLDSAIRRRFEKRIYIPLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYS 337

  Fly   688 GSDLTALAKDAALEPIREL----NVEQVK-----------------C------------LDISAM 719
            |:|::.:.:||.::|:|::    :.::|:                 |            :|:...
Human   338 GADISIIVRDALMQPVRKVQSATHFKKVRGPSRADPNHLVDDLLTPCSPGDPGAIEMTWMDVPGD 402

  Fly   720 R----AITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
            :    .::..|...||...:.:|....|...:|:::|:|
Human   403 KLLEPVVSMSDMLRSLSNTKPTVNEHDLLKLKKFTEDFG 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	17/73 (23%)
		P-loop_NTPase	482..>538	CDD:304359	34/55 (62%)
		AAA	515..652	CDD:214640	78/137 (57%)
		AAA	519..650	CDD:278434	75/131 (57%)
		Vps4_C	<722..754	CDD:286426	7/31 (23%)
VPS4B	NP_004860.2	MIT_VPS4	6..81	CDD:239141	22/100 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..117		12/134 (9%)
		SpoVK	<124..355	CDD:223540	116/232 (50%)
		Vps4_C	381..441	CDD:312737	9/59 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910