Protein Alignment spas and TRIP13

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_004228.1
• Gene: TRIP13 / 9319
• HGNCID: 12307
• Length: 432
• Species: Homo sapiens
• Alignment Length: 308
• Identity: 68/308 - (22%)
• Similarity: 125/308 - (40%)
• Gaps: 72/308 - (23%)

  Fly   441 INNNGPSGSGASTPVVSVKGVEQKLVQLI-LDEIVEGGAKVE--WTDIAGQDVAKQALQEMVIL- 501
            :|.:|||.          :.:|::...:| .:..|...|:..  |..:......|..|.:.|:.
Human   102 LNEDGPSS----------ENLEEETENIIAANHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTT 156

  Fly   502 -----PSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECS---------ATFLNISAASL 552
                 .:|...|.|..|.    :||.||||.|||.|.:|:|.:.:         ...:.|::.||
Human   157 LLFSDKNVNSNLITWNRV----VLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSL 217

  Fly   553 TSKYVGDGEKLVRALFAVARHM---QPSIIF--IDEVDSLLSERSS----SEHEASRRLKTEFLV 608
            .||:..:..|||..:|...:.:   :.:::|  ||||:||.:.|::    :|...:.|:....|.
Human   218 FSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDEVESLTAARNACRAGTEPSDAIRVVNAVLT 282

  Fly   609 EFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQT------------------ 655
            :.|.:..:   ..:|:|..:|..:::|.|.:.|...:.|:..|....
Human   283 QIDQIKRH---SNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQII 344

  Fly   656 ---------RELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTAL 694
                     |||.:...::...|.|.. .|..:::.::|.||..|..|
Human   345 YPRQQLLTLRELEMIGFIENNVSKLSL-LLNDISRKSEGLSGRVLRKL 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	19/61 (31%)
		AAA	515..652	CDD:214640	40/154 (26%)
		AAA	519..650	CDD:278434	40/148 (27%)
		Vps4_C	<722..754	CDD:286426
TRIP13	NP_004228.1	SpoVK	<136..360	CDD:223540	52/230 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900