DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and SAP1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_010966.1	Gene:	SAP1 / 856771	SGDID:	S000000849	Length:	897	Species:	Saccharomyces cerevisiae

Alignment Length:	790	Identity:	235/790 - (29%)
Similarity:	351/790 - (44%)	Gaps:	212/790 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 IFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLSNQPQRFRPI 203
            :|:.:.|...|.:  .:|..|..:....|.|   ..|..:.:.:.|..|.:..:::     |.|.
Yeast   142 VFQMVPGRMMKTL--RNRNACGYKTAYSNPS---LSSYGNSTSIKRGEDAENIRVN-----FVPS 196

  Fly   204 QPLEMAANRPGGGYSPGP---GDPLLAKQKHHHRRAFEYISKALKIDEENE----------GHKE 255
            :||...|:|    ....|   .||.|.|:...:  :.:|||:.:.||..|:          ||..
Yeast   197 KPLSNNASR----QHKNPIEHNDPPLKKETELY--SDKYISEPILIDLTNDEDDHDVGILKGHNV 255

  Fly   256 LAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFL-ALREQ--DLQM 317
            ..        :|..||...|.    .|.:|....:..:.:......|.|:..| |:::|  ||.:
Yeast   256 FD--------EEESDGFEFDV----SDYYDNFSEVDVEEEEEEKEERRRIKTLEAIQQQMSDLSV 308

  Fly   318 QRLSLKEKQKEEAQSKPQK------TREPMLAGMTNEPMKLRVRSSGYG---------------- 360
            ...:...|....:::.|..      |..|.|..:...|:....|:|..|
Yeast   309 TSSTSSNKSVSSSENVPGSCIQSLPTTAPALPSLPPPPLLNVDRASSTGALKPHSLETSTTMDSS 373

  Fly   361 -------------------------PKATTSAQPTASGRKLTIGSKRPV---NLAVANKSQTLPR 397
                                     |...|.:.||...|..:  :.:|:   |.:....|.|:|.
Yeast   374 KIRNPQISKLMKNNHVPYLKGTKSTPTLITKSTPTFITRSKS--NTKPIIKSNASSPTSSLTVPN 436

  Fly   398 NLGSKTSVGA-----------VQRQPA-------------KTAATPPAVRRQFSSGRNTPPQRSR 438
            ::..|....|           |...||             |||..|.      ||.:.|....||
Yeast   437 SVIQKPKTAAMAAKRVLNSKKVASNPALNTTKKSHPILKSKTAKVPN------SSSKKTSSHPSR 495

  Fly   439 TPINNNGPSGSGAS---------------------------TPVV-------------------- 456
             |::|:.|...|||                           :|.:
Yeast   496 -PVSNSKPYSHGASQNKKPSKNQTTSMSKTNRKIPAQKKIGSPKIEDVGTEDATEHATSLNEQRE 559

  Fly   457 -------------------SVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILP 502
                               |::||:::..:.|..|||..|.:|.|.||||.:.||.:|:|.|:.|
Yeast   560 EPEIDKKVLREILEDEIIDSLQGVDRQAAKQIFAEIVVHGDEVHWDDIAGLESAKYSLKEAVVYP 624

  Fly   503 SVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRAL 567
            .:||:||.|||.|.:|:|||||||.|||:||||||||..:||.:|||:||||||:|:.|||||||
Yeast   625 FLRPDLFRGLREPVRGMLLFGPPGTGKTMLARAVATESHSTFFSISASSLTSKYLGESEKLVRAL 689

  Fly   568 FAVARHMQPSIIFIDEVDSLLSERSS-SEHEASRRLKTEFLVEFDGLP----------------- 614
            ||:|:.:.|||||:||:||::..|:: :|:|:|||:|.||||::..|.
Yeast   690 FAIAKKLSPSIIFVDEIDSIMGSRNNENENESSRRIKNEFLVQWSSLSSAAAGSNKSNTNNSDTN 754

  Fly   615 GNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRL 679
            |:.|..|::||||||.|..:||||.|||.:|.|:.||::|||.:...:||..|...|.......|
Yeast   755 GDEDDTRVLVLAATNLPWSIDEAARRRFVRRQYIPLPEDQTRHVQFKKLLSHQKHTLTESDFDEL 819

  Fly   680 AKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLN 744
            .|||:||||||:|:||||||:.|:|:|. :::...:...:|.|...||.:||..|:.||:...|.
Yeast   820 VKITEGYSGSDITSLAKDAAMGPLRDLG-DKLLETEREMIRPIGLVDFKNSLVYIKPSVSQDGLV 883

  Fly   745 SYEKWSQDYG 754
            .||||:..:|
Yeast   884 KYEKWASQFG 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	16/87 (18%)
		P-loop_NTPase	482..>538	CDD:304359	35/55 (64%)
		AAA	515..652	CDD:214640	83/154 (54%)
		AAA	519..650	CDD:278434	80/148 (54%)
		Vps4_C	<722..754	CDD:286426	13/31 (42%)
SAP1	NP_010966.1	Herpes_BLLF1	<353..543	CDD:282904	33/198 (17%)
SAP1	NP_010966.1	SpoVK	<557..890	CDD:223540	152/333 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345777
Domainoid	1	1.000	155	1.000	Domainoid score	I895
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	1	1.000	-	-		otm46910
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	1	1.100	-	-	LDO	PTHR23074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2807
SonicParanoid	1	1.000	-	-		X3342
TreeFam	0	0.000	Not matched by this tool.
	10	9.770