DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and YME1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_015349.1	Gene:	YME1 / 856135	SGDID:	S000006228	Length:	747	Species:	Saccharomyces cerevisiae

Alignment Length:	438	Identity:	128/438 - (29%)
Similarity:	197/438 - (44%)	Gaps:	75/438 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 SLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVN 385
            |:...|.....:...||::..:| :::..:..|.:.:.   |..||....|:..||.:.|..|..
Yeast    76 SIDNSQPPPPSNTNDKTKQANVA-VSHAMLATREQEAN---KDLTSPDAQAAFYKLLLQSNYPQY 136

  Fly   386 L-------AVANKSQTLP------RNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRS 437
            :       .:|:..:.:.      :.:|..:...|| ||...||::..||....:|..:     :
Yeast   137 VVSRFETPGIASSPECMELYMEALQRIGRHSEADAV-RQNLLTASSAGAVNPSLASSSS-----N 195

  Fly   438 RTPINNNGPS------GS---------GASTPVVSVKGVEQKLVQLILDEIVEGGAK-------- 479
            ::..:.|.||      ||         ..||..|..:.|:..||..||......|.|
Yeast   196 QSGYHGNFPSMYSPLYGSRKEPLHVVVSESTFTVVSRWVKWLLVFGILTYSFSEGFKYITENTTL 260

  Fly   480 -----------------VEWTDIAGQDVAKQALQEMVIL---PSVRPELFTGLRAPAKGLLLFGP 524
                             |::.|:.|.|.|:..|:|:|..   |:....|  |.:.| ||:||.||
Yeast   261 LKSSEVADKSVDVAKTNVKFDDVCGCDEARAELEEIVDFLKDPTKYESL--GGKLP-KGVLLTGP 322

  Fly   525 PGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLS 589
            ||.||||||||.|.|....|..:|.:.....|||.|.|.:|.|||.||...|:||||||:|::..
Yeast   323 PGTGKTLLARATAGEAGVDFFFMSGSEFDEVYVGVGAKRIRDLFAQARSRAPAIIFIDELDAIGG 387

  Fly   590 ERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPD 652
            :|:..:...:::...:.|||.||. ....|  |:::.|||.|:.||:|..|  ||.|.|.|.|||
Yeast   388 KRNPKDQAYAKQTLNQLLVELDGF-SQTSG--IIIIGATNFPEALDKALTRPGRFDKVVNVDLPD 449

  Fly   653 EQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAAL 700
            .:.|..:|...::|. :..|......:|:.|.|.||::|..|...||:
Yeast   450 VRGRADILKHHMKKI-TLADNVDPTIIARGTPGLSGAELANLVNQAAV 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	27/58 (47%)
		AAA	515..652	CDD:214640	62/138 (45%)
		AAA	519..650	CDD:278434	58/132 (44%)
		Vps4_C	<722..754	CDD:286426
YME1	NP_015349.1	HflB	227..712	CDD:223541	96/277 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910