DRSC/TRiP Functional Genomics Resources

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Protein Alignment spas and YME1

DIOPT Version :9

Sequence 1:NP_651206.3 Gene:spas / 42846 FlyBaseID:FBgn0039141 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_015349.1 Gene:YME1 / 856135 SGDID:S000006228 Length:747 Species:Saccharomyces cerevisiae


Alignment Length:438 Identity:128/438 - (29%)
Similarity:197/438 - (44%) Gaps:75/438 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   321 SLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVN 385
            |:...|.....:...||::..:| :::..:..|.:.:.   |..||....|:..||.:.|..|..
Yeast    76 SIDNSQPPPPSNTNDKTKQANVA-VSHAMLATREQEAN---KDLTSPDAQAAFYKLLLQSNYPQY 136

  Fly   386 L-------AVANKSQTLP------RNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRS 437
            :       .:|:..:.:.      :.:|..:...|| ||...||::..||....:|..:     :
Yeast   137 VVSRFETPGIASSPECMELYMEALQRIGRHSEADAV-RQNLLTASSAGAVNPSLASSSS-----N 195

  Fly   438 RTPINNNGPS------GS---------GASTPVVSVKGVEQKLVQLILDEIVEGGAK-------- 479
            ::..:.|.||      ||         ..||..|..:.|:..||..||......|.|        
Yeast   196 QSGYHGNFPSMYSPLYGSRKEPLHVVVSESTFTVVSRWVKWLLVFGILTYSFSEGFKYITENTTL 260

  Fly   480 -----------------VEWTDIAGQDVAKQALQEMVIL---PSVRPELFTGLRAPAKGLLLFGP 524
                             |::.|:.|.|.|:..|:|:|..   |:....|  |.:.| ||:||.||
Yeast   261 LKSSEVADKSVDVAKTNVKFDDVCGCDEARAELEEIVDFLKDPTKYESL--GGKLP-KGVLLTGP 322

  Fly   525 PGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLS 589
            ||.||||||||.|.|....|..:|.:.....|||.|.|.:|.|||.||...|:||||||:|::..
Yeast   323 PGTGKTLLARATAGEAGVDFFFMSGSEFDEVYVGVGAKRIRDLFAQARSRAPAIIFIDELDAIGG 387

  Fly   590 ERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPD 652
            :|:..:...:::...:.|||.||. ....|  |:::.|||.|:.||:|..|  ||.|.|.|.|||
Yeast   388 KRNPKDQAYAKQTLNQLLVELDGF-SQTSG--IIIIGATNFPEALDKALTRPGRFDKVVNVDLPD 449

  Fly   653 EQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAAL 700
            .:.|..:|...::|. :..|......:|:.|.|.||::|..|...||:
Yeast   450 VRGRADILKHHMKKI-TLADNVDPTIIARGTPGLSGAELANLVNQAAV 496

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spasNP_651206.3 MIT_spastin 230..308 CDD:239142
P-loop_NTPase 482..>538 CDD:304359 27/58 (47%)
AAA 515..652 CDD:214640 62/138 (45%)
AAA 519..650 CDD:278434 58/132 (44%)
Vps4_C <722..754 CDD:286426
YME1NP_015349.1 HflB 227..712 CDD:223541 96/277 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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