Protein Alignment spas and YTA6

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_015251.1
• Gene: YTA6 / 856031
• SGDID: S000005995
• Length: 754
• Species: Saccharomyces cerevisiae
• Alignment Length: 633
• Identity: 206/633 - (32%)
• Similarity: 326/633 - (51%)
• Gaps: 98/633 - (15%)

  Fly   184 REGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGD---------PLLAKQKHHHRRAFEY 239
            :|.|.:|.:::.|....|..:.||  ..:..|.......|         .|..|:|.....|.:.
Yeast   154 KEADEKEAKINKQADNIRRARKLE--EEKKLGAKLQYERDLELQREKLIELKVKEKVEFEVAQKL 216

  Fly   240 ISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDR 304
            ..:.:|.:||...|:|.|   .:|.|..|:                     |:: :||.......
Yeast   217 EEERVKREEEERKHREQA---EKKRISTLK---------------------HER-KTNYKSRASL 256

  Fly   305 LHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGM----------------TNEPMKLR 353
            .:|.:..:...::....:|.:..:..::..::.|.|:...|                .|.....:
Yeast   257 DNFSSSSKSSGKIDNSLIKRRSLDVVRTSGERVRTPVRKSMEAAEIGMAAQLAWSQYQNGANHSK 321

  Fly   354 VRSSG---------YGPKATTSAQPTASGRKLTIGSKRPV------NLAVANKSQTLPRN---LG 400
            |.::|         |.|  |...:.....:|.|:  .||:      |...:..|:.:|.|   ..
Yeast   322 VSNNGSHSNELQIRYKP--TPPLKKRYDYKKPTV--NRPIIKSPTLNRQNSKSSRNIPTNSKLKA 382

  Fly   401 SKTSVGAVQRQ---------PAKTAATP-PAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPV 455
            ||::...|.|:         |...:||. ||..:...|...||.:.|    :.:....|.....:
Yeast   383 SKSNTNKVSRRNEQNLEPSSPVLVSATAVPAESKPMRSKSGTPDKES----SASSSLDSRKEDIL 443

  Fly   456 VSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLL 520
            .||:||::...:.||:||:....||.|.||||...||.:|:|.|:.|.:||:||.|||.|.:|:|
Yeast   444 KSVQGVDRNACEQILNEILVTDEKVYWEDIAGLRNAKNSLKEAVVYPFLRPDLFKGLREPVRGML 508

  Fly   521 LFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVD 585
            ||||||.|||::|:|||||.::||.::||:||.|||:|:.||||||||.:|:.:.||||||||:|
Yeast   509 LFGPPGTGKTMIAKAVATESNSTFFSVSASSLLSKYLGESEKLVRALFYMAKKLSPSIIFIDEID 573

  Fly   586 SLLSERSSSEHEASRRLKTEFLVEFDGLP---------GNPDGDRIVVLAATNRPQELDEAALRR 641
            |:|:.||.:|:|:|||:|||.|:::..|.         .|....|::||.|||.|..:|:||.||
Yeast   574 SMLTARSDNENESSRRIKTELLIQWSSLSSATAQSEDRNNTLDSRVLVLGATNLPWAIDDAARRR 638

  Fly   642 FTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIREL 706
            |::::|:.|||.:||...|.||:.||.:.|.......:.::|:|:||||||:|||:||:||||:|
Yeast   639 FSRKLYIPLPDYETRLYHLKRLMAKQKNSLQDLDYELITEMTEGFSGSDLTSLAKEAAMEPIRDL 703

  Fly   707 NVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
            . :::...|...:|.|..:||.::|..|::||:.:||..||:||..:|
Yeast   704 G-DKLMFADFDKIRGIEIKDFQNALLTIKKSVSSESLQKYEEWSSKFG 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	14/77 (18%)
		P-loop_NTPase	482..>538	CDD:304359	33/55 (60%)
		AAA	515..652	CDD:214640	76/145 (52%)
		AAA	519..650	CDD:278434	73/139 (53%)
		Vps4_C	<722..754	CDD:286426	13/31 (42%)
YTA6	NP_015251.1	SpoVK	201..747	CDD:223540	195/579 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345776
Domainoid	1	1.000	155	1.000	Domainoid score	I895
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I518
Isobase	1	0.950	-	0	Normalized mean entropy	S1340
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	1	1.000	-	-		otm46910
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	1	1.100	-	-	O	PTHR23074
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3342
TreeFam	0	0.000	Not matched by this tool.
	11	10.740