DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and PEX6

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_014070.1	Gene:	PEX6 / 855387	SGDID:	S000005273	Length:	1030	Species:	Saccharomyces cerevisiae

Alignment Length:	297	Identity:	102/297 - (34%)
Similarity:	153/297 - (51%)	Gaps:	33/297 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   480 VEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATF 544
            |.|.||.|.|..|..:.:.:.:|...|||||.......|:|.:||||.||||:|:|:||..|..|
Yeast   729 VTWDDIGGIDFVKGEILDTIDMPLKHPELFTSGMKKRSGILFYGPPGTGKTLMAKAIATNFSLNF 793

  Fly   545 LNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEAS--RRLKTEFL 607
            .::....|.:.|:|:.|..||.:|..||..:|.:||.||:||:..:|.:......  .|:.::.|
Yeast   794 FSVKGPELLNMYIGESEANVRRVFQKAREAKPCVIFFDEIDSVAPKRGNQGDSGGVMDRIVSQLL 858

  Fly   608 VEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTREL-LLNRLLQKQGS 669
            .|.||:  :.|.|.:.|:.|||||..||||.||  ||.|.:|:.:||..|::| :|..|.:|  .
Yeast   859 AELDGM--STDADGVFVIGATNRPDLLDEALLRPGRFDKLLYLGIPDTDTKQLNILEALTRK--F 919

  Fly   670 PLDTEA-LRRLAKITD-GYSGSDLTALAKDAALEPIREL-----------------NVEQVKCLD 715
            .||.:. |..|||:.. .|:|:|..||..||.|..:..:                 |:...:..|
Yeast   920 VLDNDVKLIELAKLCPFNYTGADFYALCSDAMLNAMSRIARMVEKKVSQHNELTGENISTRRWFD 984

  Fly   716 ISAMRAITE-----QDFHSSLKRIRRSVAPQSLNSYE 747
            ..|.:..|:     :||..:.:::..||:...||.||
Yeast   985 KIATKEDTKVVVKMEDFLKAQEQLTPSVSRAELNHYE 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	24/55 (44%)
		AAA	515..652	CDD:214640	56/140 (40%)
		AAA	519..650	CDD:278434	55/134 (41%)
		Vps4_C	<722..754	CDD:286426	9/31 (29%)
PEX6	NP_014070.1	SpoVK	540..1017	CDD:223540	98/291 (34%)
PEX6	NP_014070.1	RecA-like_PEX6_r2	740..899	CDD:410935	62/160 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900