DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and PEX1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_012724.1	Gene:	PEX1 / 853636	SGDID:	S000001680	Length:	1043	Species:	Saccharomyces cerevisiae

Alignment Length:	237	Identity:	78/237 - (32%)
Similarity:	126/237 - (53%)	Gaps:	18/237 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   480 VEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAK---GLLLFGPPGNGKTLLARAVATECS 541
            ::|.||.....||..|.|.:..|:....:|  :..|.:   |:||:|.||.||||||.|||.:|.
Yeast   694 IKWGDIGALANAKDVLLETLEWPTKYEPIF--VNCPLRLRSGILLYGYPGCGKTLLASAVAQQCG 756

  Fly   542 ATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEF 606
            ..|:::....:.:|::|..|:.:|.||..|:.::|.|:|.||.||:..:|.......:.|:..:.
Yeast   757 LNFISVKGPEILNKFIGASEQNIRELFERAQSVKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQL 821

  Fly   607 LVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLL----- 664
            |.:.||..|.   |.:.:||||:||..:|.|.||  |..|.|..::|.|..|..:|..::
Yeast   822 LTQMDGAEGL---DGVYILAATSRPDLIDSALLRPGRLDKSVICNIPTESERLDILQAIVNSKDK 883

  Fly   665 ---QKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPI 703
               ||:.:......|:.:|:.|.|:||:||..|..:|.|:.:
Yeast   884 DTGQKKFALEKNADLKLIAEKTAGFSGADLQGLCYNAYLKSV 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	24/58 (41%)
		AAA	515..652	CDD:214640	52/141 (37%)
		AAA	519..650	CDD:278434	50/132 (38%)
		Vps4_C	<722..754	CDD:286426
PEX1	NP_012724.1	PEX-1N	108..183	CDD:401267
		SpoVK	457..929	CDD:223540	78/237 (33%)
		RecA-like_PEX1_r2	705..862	CDD:410934	58/161 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810