DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and MSP1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_011542.3	Gene:	MSP1 / 852915	SGDID:	S000003260	Length:	362	Species:	Saccharomyces cerevisiae

Alignment Length:	351	Identity:	122/351 - (34%)
Similarity:	179/351 - (50%)	Gaps:	63/351 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 VQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDE 472
            |:|.||....|..|..|...|...||                                     ||
Yeast    58 VKRSPALAEVTLDAYERTILSSIVTP-------------------------------------DE 85

  Fly   473 IVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTG---LRAPAKGLLLFGPPGNGKTLLAR 534
            |     .:.:.||.|.|.....|.|.||.|.:.||:::.   |:||: |:||:||||.|||:||:
Yeast    86 I-----NITFQDIGGLDPLISDLHESVIYPLMMPEVYSNSPLLQAPS-GVLLYGPPGCGKTMLAK 144

  Fly   535 AVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEAS 599
            |:|.|..|.|::|..:|:..|:.|:..|:|.|:|::|..:||.||||||:||.|.||||::||.:
Yeast   145 ALAKESGANFISIRMSSIMDKWYGESNKIVDAMFSLANKLQPCIIFIDEIDSFLRERSSTDHEVT 209

  Fly   600 RRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLL 664
            ..||.||:..:|||..|   .|::::.||||..::|:|.|||..||..||||....|..:|:.||
Yeast   210 ATLKAEFMTLWDGLLNN---GRVMIIGATNRINDIDDAFLRRLPKRFLVSLPGSDQRYKILSVLL 271

  Fly   665 QKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISA----------M 719
            :......|...|:.:|..|.|:|||||..|.::|||:..:|...::.:.:|...          :
Yeast   272 KDTKLDEDEFDLQLIADNTKGFSGSDLKELCREAALDAAKEYIKQKRQLIDSGTIDVNDTSSLKI 336

  Fly   720 RAITEQDFHSSLKRIRRSVAPQSLNS 745
            |.:..:||...|    |..|..:|:|
Yeast   337 RPLKTKDFTKKL----RMDATSTLSS 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	27/58 (47%)
		AAA	515..652	CDD:214640	67/136 (49%)
		AAA	519..650	CDD:278434	63/130 (48%)
		Vps4_C	<722..754	CDD:286426	7/24 (29%)
MSP1	NP_011542.3	MDN1	<10..>164	CDD:227596	46/148 (31%)
		RecA-like_ATAD1	92..255	CDD:410928	77/166 (46%)
		AAA_lid_3	280..319	CDD:407720	14/38 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810