Protein Alignment spas and PCH2

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_009745.2
• Gene: PCH2 / 852484
• SGDID: S000000390
• Length: 564
• Species: Saccharomyces cerevisiae
• Alignment Length: 615
• Identity: 117/615 - (19%)
• Similarity: 189/615 - (30%)
• Gaps: 244/615 - (39%)

  Fly   145 GASTKVIYRPHRRDCNIEIV------VQNSSKEQQQSLN------------HP-----------S 180
            |:|.:||....|.|..|..:      .|||:|:..:.||            .|           .
Yeast    11 GSSLRVIKCMFREDEQISSLHSGSDSKQNSNKKLGEFLNLLKAVVKRKLESFPKDRLKTSIITGQ 75

  Fly   181 ELNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKAL- 244
            ||.|||.|.                :|:.             ||....|:|..|.    ::|.|
Yeast    76 ELMREGQGS----------------IEIK-------------DPPTEAQQHLIRS----LAKVLL 107

  Fly   245 --------KIDEENEGHKELAIELYRKGI---KELEDGIAVDC-WSGRGDVWDRAQRLHDKMQTN 297
                    |::..|||...|.:.|:.|.|   ::....:::.. :..:.::......:.|..:||
Yeast   108 HQFSSINGKVNTVNEGQDNLFLSLFVKKISIEQQSTSHVSIKLNFHEKINLGQHIDSILDSEETN 172

  Fly   298 LSMARDRLH-----------FLALREQD---------LQMQRLSLKEKQKEEAQSKPQKTREPML 342
            .|   |..|           |..|.|||         .:..::.|:..:.:
Yeast   173 ES---DTYHMGSVDEFIIYPFCCLEEQDELKNGSILSTEFDKIDLELDEDD-------------- 220

  Fly   343 AGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGA 407
             |...|.:...:.|.|                          |..:....|||  ||
Yeast   221 -GFEGETLNNCINSVG--------------------------NFDIPLSKQTL--NL-------- 248

  Fly   408 VQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKL-----VQ 467
                          |...:..|.....|.......||                ::::|     :.
Yeast   249 --------------VNISYLPGTTFEGQWESLYFGNN----------------IKERLYSYATIS 283

  Fly   468 LILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLL 532
            |.:....:.|      |...:|:                   |.|....|.||:.||||.|||.|
Yeast   284 LKIARFKQTG------DSNQEDI-------------------TTLITNNKLLLVHGPPGTGKTTL 323

  Fly   533 ARA-----------------VATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQP---- 576
            .:|                 :.|......:.:|.|.:.||:.|:..|.:..:|.....:..
Yeast   324 CKALCQKLSVRREFSDGSDTIDTNYKGIIIELSCARIFSKWFGESSKNISIVFKDIEELLKVNEG 388

  Fly   577 ----SIIFIDEVDSLLSERS--SSEHEASR--RLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQE 633
                ..:.||||:::.|.|:  ||.:|::.  |:....|.:.|.|   ......:.||.:|....
Yeast   389 RGIFICLLIDEVEAIASSRTNLSSRNESTDGIRVVNTLLTQLDRL---KKYHNFLALATSNLLDS 450

  Fly   634 LDEAALRRFTKRVYVSLPDEQTRELLLNRL 663
            ||:|.:.|.....||..|   |.|.:|:.|
Yeast   451 LDDAFVDRADGVFYVGNP---TAEGILHIL 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	18/101 (18%)
		P-loop_NTPase	482..>538	CDD:304359	16/72 (22%)
		AAA	515..652	CDD:214640	42/165 (25%)
		AAA	519..650	CDD:278434	41/159 (26%)
		Vps4_C	<722..754	CDD:286426
PCH2	NP_009745.2	SpoVK	1..487	CDD:223540	117/615 (19%)
		P-loop_NTPase	248..465	CDD:422963	53/282 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900