DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and SEC18

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_009636.3	Gene:	SEC18 / 852372	SGDID:	S000000284	Length:	758	Species:	Saccharomyces cerevisiae

Alignment Length:	291	Identity:	87/291 - (29%)
Similarity:	142/291 - (48%)	Gaps:	45/291 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   471 DEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARA 535
            :::..||...|:|.|     .::|....:..|||..:|  |: :..|||||:||||.||||:||.
Yeast   237 EDLGVGGLDKEFTKI-----FRRAFASRIFPPSVIEKL--GI-SHVKGLLLYGPPGTGKTLIARK 293

  Fly   536 VATECSATFLNI-SAASLTSKYVGDGEKLVRALF--------AVARHMQPSIIFIDEVDSLLSER 591
            :.|..:|....| :...:.|||||..|:.:|.||        |........||..||:||:..:|
Yeast   294 IGTMLNAKEPKIVNGPEILSKYVGSSEENIRNLFKDAEAEYRAKGEESSLHIIIFDELDSVFKQR 358

  Fly   592 SS--SEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPD 652
            .|  ........:..:.|.:.||:   ...:.|:|:..|||...:|.|.||  ||..:|.:.|||
Yeast   359 GSRGDGTGVGDNVVNQLLAKMDGV---DQLNNILVIGMTNRKDLIDSALLRPGRFEVQVEIHLPD 420

  Fly   653 E---------QTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPI-RELN 707
            |         ||:::..|.::.      |...|..||.:|..:||:::..|.|.|:...| :.:|
Yeast   421 EKGRLQIFDIQTKKMRENNMMS------DDVNLAELAALTKNFSGAEIEGLVKSASSFAINKTVN 479

  Fly   708 V----EQVKCLDISAMRAITEQDFHSSLKRI 734
            :    .::...||:.:: :|.:||.::|..:
Yeast   480 IGKGATKLNTKDIAKLK-VTREDFLNALNDV 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	23/55 (42%)
		AAA	515..652	CDD:214640	52/149 (35%)
		AAA	519..650	CDD:278434	49/143 (34%)
		Vps4_C	<722..754	CDD:286426	4/13 (31%)
SEC18	NP_009636.3	CDC48_N	29..98	CDD:215012
		CDC48_2	134..204	CDD:215011
		RecA-like_NSF-SEC18_r1-like	240..416	CDD:410912	62/186 (33%)
		SpoVK	263..758	CDD:223540	81/260 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900