DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and CDC48

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_010157.1	Gene:	CDC48 / 851431	SGDID:	S000002284	Length:	835	Species:	Saccharomyces cerevisiae

Alignment Length:	741	Identity:	187/741 - (25%)
Similarity:	301/741 - (40%)	Gaps:	183/741 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 YVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCN---------IEIVVQNSSKE 171
            |.....::.:.:.:..:...||.:|...|....   |||.|:..:         :|..|.:...|
Yeast   120 YATRISVLPIADTIEGITGNLFDVFLKPYFVEA---YRPVRKGDHFVVRGGMRQVEFKVVDVEPE 181

  Fly   172 Q-----QQSLNH--PSELNREGD-------------GQEQQLS----------NQPQRFRPIQPL 206
            :     |.::.|  ...:|||.:             |..:|::          ..||.|:.|
Yeast   182 EYAVVAQDTIIHWEGEPINREDEENNMNEVGYDDIGGCRKQMAQIREMVELPLRHPQLFKAI--- 243

  Fly   207 EMAANRPGGGY----SPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKE 267
               ..:|..|.    .||.|..|:|:...:...||.::....::..:..|..|..:   ||..:|
Yeast   244 ---GIKPPRGVLMYGPPGTGKTLMARAVANETGAFFFLINGPEVMSKMAGESESNL---RKAFEE 302

  Fly   268 LE------------DGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRL 320
            .|            |.||.......|:|                            |:.:..|.|
Yeast   303 AEKNAPAIIFIDEIDSIAPKRDKTNGEV----------------------------ERRVVSQLL 339

  Fly   321 SLKEKQKEEAQSKPQKTREPMLAGMTNEPMKL--RVRSSGYGPKATTSAQPTASGR--KLTIGSK 381
            :|.:..|..:        ..::...||.|..:  .:|..|...:......|.|:||  .|.|.:|
Yeast   340 TLMDGMKARS--------NVVVIAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEVLRIHTK 396

  Fly   382 RPVNLAVAN-------KSQT---LPRNLGSKTSVGAVQRQPAK---TAATPPAVRRQFSSGRNTP 433
               |:.:|:       .::|   :..::.|..|..|:|:...|   .......:..:........
Yeast   397 ---NMKLADDVDLEALAAETHGYVGADIASLCSEAAMQQIREKMDLIDLDEDEIDAEVLDSLGVT 458

  Fly   434 PQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEM 498
            ....|..:.|:.||.                     |.|.|.....|.|.|:.|.|..|:.|:|.
Yeast   459 MDNFRFALGNSNPSA---------------------LRETVVESVNVTWDDVGGLDEIKEELKET 502

  Fly   499 VILPSVRPELFT--GLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGE 561
            |..|.:.|:.:|  || :|:||:|.:||||.||||||:|||||.||.|:::....|.|.:.|:.|
Yeast   503 VEYPVLHPDQYTKFGL-SPSKGVLFYGPPGTGKTLLAKAVATEVSANFISVKGPELLSMWYGESE 566

  Fly   562 KLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHE---ASRRLKTEFLVEFDGLPGNPDGDRIV 623
            ..:|.:|..||...|:::|:||:||:...|..|..:   ||.|:..:.|.|.||:....:   :.
Yeast   567 SNIRDIFDKARAAAPTVVFLDELDSIAKARGGSLGDAGGASDRVVNQLLTEMDGMNAKKN---VF 628

  Fly   624 VLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTE-ALRRLAKITDG 685
            |:.|||||.::|.|.||  |..:.:||.||||..|..:||..|:|  :||:.. .|..:||.|.|
Yeast   629 VIGATNRPDQIDPAILRPGRLDQLIYVPLPDENARLSILNAQLRK--TPLEPGLELTAIAKATQG 691

  Fly   686 YSGSDLTALAKDAAL-------------EPIRELNV--EQVKCLD----------ISAMRAITEQ 725
            :||:||..:.:.||.             |..:|:.|  |.|:..|          :..:..||::
Yeast   692 FSGADLLYIVQRAAKYAIKDSIEAHRQHEAEKEVKVEGEDVEMTDEGAKAEQEPEVDPVPYITKE 756

  Fly   726 DFHSSLKRIRRSVAPQSLNSYEKWSQ 751
            .|..::|..:|||:...|..||.:||
Yeast   757 HFAEAMKTAKRSVSDAELRRYEAYSQ 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	13/89 (15%)
		P-loop_NTPase	482..>538	CDD:304359	29/57 (51%)
		AAA	515..652	CDD:214640	59/141 (42%)
		AAA	519..650	CDD:278434	55/135 (41%)
		Vps4_C	<722..754	CDD:286426	12/30 (40%)
CDC48	NP_010157.1	CDC48	48..785	CDD:273521	187/741 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810