Protein Alignment spas and CDC48

DIOPT Version :10

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_010157.1
• Gene: CDC48 / 851431
• SGDID: S000002284
• Length: 835
• Species: Saccharomyces cerevisiae
• Alignment Length: 741
• Identity: 187/741 - (25%)
• Similarity: 301/741 - (40%)
• Gaps: 183/741 - (24%)

  Fly   116 YVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCN---------IEIVVQNSSKE 171
            |.....::.:.:.:..:...||.:|...|....   |||.|:..:         :|..|.:...|
Yeast   120 YATRISVLPIADTIEGITGNLFDVFLKPYFVEA---YRPVRKGDHFVVRGGMRQVEFKVVDVEPE 181

  Fly   172 Q-----QQSLNH--PSELNREGD-------------GQEQQLS----------NQPQRFRPIQPL 206
            :     |.::.|  ...:|||.:             |..:|::          ..||.|:.|
Yeast   182 EYAVVAQDTIIHWEGEPINREDEENNMNEVGYDDIGGCRKQMAQIREMVELPLRHPQLFKAI--- 243

  Fly   207 EMAANRPGGGY----SPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKE 267
               ..:|..|.    .||.|..|:|:...:...||.::....::..:..|..|..:   ||..:|
Yeast   244 ---GIKPPRGVLMYGPPGTGKTLMARAVANETGAFFFLINGPEVMSKMAGESESNL---RKAFEE 302

  Fly   268 LE------------DGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRL 320
            .|            |.||.......|:|                            |:.:..|.|
Yeast   303 AEKNAPAIIFIDEIDSIAPKRDKTNGEV----------------------------ERRVVSQLL 339

  Fly   321 SLKEKQKEEAQSKPQKTREPMLAGMTNEPMKL--RVRSSGYGPKATTSAQPTASGR--KLTIGSK 381
            :|.:..|..:        ..::...||.|..:  .:|..|...:......|.|:||  .|.|.:|
Yeast   340 TLMDGMKARS--------NVVVIAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEVLRIHTK 396

  Fly   382 RPVNLAVAN-------KSQT---LPRNLGSKTSVGAVQRQPAK---TAATPPAVRRQFSSGRNTP 433
               |:.:|:       .::|   :..::.|..|..|:|:...|   .......:..:........
Yeast   397 ---NMKLADDVDLEALAAETHGYVGADIASLCSEAAMQQIREKMDLIDLDEDEIDAEVLDSLGVT 458

  Fly   434 PQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEM 498
            ....|..:.|:.||.                     |.|.|.....|.|.|:.|.|..|:.|:|.
Yeast   459 MDNFRFALGNSNPSA---------------------LRETVVESVNVTWDDVGGLDEIKEELKET 502

  Fly   499 VILPSVRPELFT--GLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGE 561
            |..|.:.|:.:|  || :|:||:|.:||||.||||||:|||||.||.|:::....|.|.:.|:.|
Yeast   503 VEYPVLHPDQYTKFGL-SPSKGVLFYGPPGTGKTLLAKAVATEVSANFISVKGPELLSMWYGESE 566

  Fly   562 KLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHE---ASRRLKTEFLVEFDGLPGNPDGDRIV 623
            ..:|.:|..||...|:::|:||:||:...|..|..:   ||.|:..:.|.|.||:....:   :.
Yeast   567 SNIRDIFDKARAAAPTVVFLDELDSIAKARGGSLGDAGGASDRVVNQLLTEMDGMNAKKN---VF 628

  Fly   624 VLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTE-ALRRLAKITDG 685
            |:.|||||.::|.|.||  |..:.:||.||||..|..:||..|:|  :||:.. .|..:||.|.|
Yeast   629 VIGATNRPDQIDPAILRPGRLDQLIYVPLPDENARLSILNAQLRK--TPLEPGLELTAIAKATQG 691

  Fly   686 YSGSDLTALAKDAAL-------------EPIRELNV--EQVKCLD----------ISAMRAITEQ 725
            :||:||..:.:.||.             |..:|:.|  |.|:..|          :..:..||::
Yeast   692 FSGADLLYIVQRAAKYAIKDSIEAHRQHEAEKEVKVEGEDVEMTDEGAKAEQEPEVDPVPYITKE 756

  Fly   726 DFHSSLKRIRRSVAPQSLNSYEKWSQ 751
            .|..::|..:|||:...|..||.:||
Yeast   757 HFAEAMKTAKRSVSDAELRRYEAYSQ 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	13/89 (15%)
		RecA-like_spastin	484..648	CDD:410932	68/170 (40%)
		AAA_lid_3	676..727	CDD:465537	19/75 (25%)
		Vps4_C	<722..754	CDD:462762	12/30 (40%)
CDC48	NP_010157.1	CDC48	48..785	CDD:273521	187/741 (25%)