Protein Alignment spas and AFG2

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_013501.1
• Gene: AFG2 / 851113
• SGDID: S000004389
• Length: 780
• Species: Saccharomyces cerevisiae
• Alignment Length: 734
• Identity: 190/734 - (25%)
• Similarity: 287/734 - (39%)
• Gaps: 193/734 - (26%)

  Fly    78 GDDD-----TTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSFPIIFLFNVLRSLIYQLF 137
            ||:.     |..:||..|............|||.      .||:.:|.|.||
Yeast   172 GDESIDVVITDASDDSLPDVSQLDLNMDDMYGGL------DNLFYLSPPFIF------------- 217

  Fly   138 CIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQ--QSLNHPSELNREG-DGQEQQLS----- 194
                  ...||.:.:                |||.|  :..|.|..|:... .|.::::.
Yeast   218 ------RKGSTHITF----------------SKETQANRKYNLPEPLSYAAVGGLDKEIESLKSA 260

  Fly   195 -----NQPQRFRPI---QPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENE 251
                 :||..|...   .|..:..:.|     ||.|..:|.:...:...|.........|..:..
Yeast   261 IEIPLHQPTLFSSFGVSPPRGILLHGP-----PGTGKTMLLRVVANTSNAHVLTINGPSIVSKYL 320

  Fly   252 GHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNL-------SMARDRLHFLA 309
            |..|.|:.                      |:::.|:    |.|.::       |:|.:|.:
Yeast   321 GETEAALR----------------------DIFNEAR----KYQPSIIFIDEIDSIAPNRAN--- 356

  Fly   310 LREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGM-----------TNEPMKL--RVRSSGYGP 361
                           ....|.:|:...|...::.||           ||.|..:  .:|..|...
Yeast   357 ---------------DDSGEVESRVVATLLTLMDGMGAAGKVVVIAATNRPNSVDPALRRPGRFD 406

  Fly   362 KATTSAQPTASGR--KLT-----IGSKRPVNLAVANKSQTLPRNLGSKTS--VGAVQRQPAKTAA 417
            :......|....|  .||     :.|.|.|..:.|.|      .:.|||.  |||     ..||.
Yeast   407 QEVEIGIPDVDARFDILTKQFSRMSSDRHVLDSEAIK------YIASKTHGYVGA-----DLTAL 460

  Fly   418 TPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQL---ILDEIVEGGAK 479
            ...:|.:....|..|.....:..:.             |::|.||..:|.:   .:.||.....|
Yeast   461 CRESVMKTIQRGLGTDANIDKFSLK-------------VTLKDVESAMVDIRPSAMREIFLEMPK 512

  Fly   480 VEWTDIAGQDVAKQALQEMVILPSVRPELFT--GLRAPAKGLLLFGPPGNGKTLLARAVATECSA 542
            |.|:||.||:..|..::||:.||....|.|.  |:.|| ||:||:||||..|||.|:|:|||...
Yeast   513 VYWSDIGGQEELKTKMKEMIQLPLEASETFARLGISAP-KGVLLYGPPGCSKTLTAKALATESGI 576

  Fly   543 TFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFL 607
            .||.:....:.:||||:.|:.:|.:|..||...|||||.||:|:|..:|..|...|:..:.|..|
Yeast   577 NFLAVKGPEIFNKYVGESERAIREIFRKARSAAPSIIFFDEIDALSPDRDGSSTSAANHVLTSLL 641

  Fly   608 VEFDG---LPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQ 667
            .|.||   |.|      :|::||||||.|:|.|.||  |..:.:||..||...|..:|.:..:|.
Yeast   642 NEIDGVEELKG------VVIVAATNRPDEIDAALLRPGRLDRHIYVGPPDVNARLEILKKCTKKF 700

  Fly   668 GSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRE-LNVEQVKCLDISAMRAITEQDFHSSL 731
            .:......|..||..|:||||:::..|.::|.|..|.| |:|.:|:.           :.|..:.
Yeast   701 NTEESGVDLHELADRTEGYSGAEVVLLCQEAGLAAIMEDLDVAKVEL-----------RHFEKAF 754

  Fly   732 KRIRRSVAPQSLNSYEKWS 750
            |.|.|.:.|:.|:.||:::
Yeast   755 KGIARGITPEMLSYYEEFA 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	12/84 (14%)
		P-loop_NTPase	482..>538	CDD:304359	28/57 (49%)
		AAA	515..652	CDD:214640	62/141 (44%)
		AAA	519..650	CDD:278434	59/135 (44%)
		Vps4_C	<722..754	CDD:286426	8/29 (28%)
AFG2	NP_013501.1	CDC48	51..773	CDD:273521	190/732 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810