DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and RIX7

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_013066.1	Gene:	RIX7 / 850625	SGDID:	S000003957	Length:	837	Species:	Saccharomyces cerevisiae

Alignment Length:	562	Identity:	159/562 - (28%)
Similarity:	260/562 - (46%)	Gaps:	115/562 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 DVWDRAQRL------HDKMQTNLSMARDRLHFLALREQDLQM--QRL-SLKEKQKEEAQSKPQKT 337
            |::|.|:.|      .|::.. ::..||.   .|.||.:.::  |.| |:.|...|:...||
Yeast   289 DLFDEARSLAPCLVFFDEIDA-ITPKRDG---GAQREMERRIVAQLLTSMDELTMEKTNGKP--- 346

  Fly   338 REPMLAGMTNEPMKL--RVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAV------ANKSQT 394
              .::.|.||.|..|  .:|.:|...:......|....| |.|..|...||.:      |..::.
Yeast   347 --VIIIGATNRPDSLDAALRRAGRFDREICLNVPNEVSR-LHILKKMSDNLKIDGAIDFAKLAKL 408

  Fly   395 LPRNLGS--KTSVGAVQRQPAKTAATPPAVRRQFSSGRN---TPPQRSRTPINN-------NGPS 447
            .|..:|:  |..|         |||...|::|.|.:..|   ||...:.:..:|       ||..
Yeast   409 TPGFVGADLKALV---------TAAGTCAIKRIFQTYANIKSTPTTATDSSEDNMEIDETANGDE 464

  Fly   448 GSGAST-------PVVSVK-----------GVEQKLVQLILDEIV------------EGGA---K 479
            .|..:|       |:..|:           |.:..|:.:..::.:            ||.|   .
Yeast   465 SSLKNTANMIDPLPLSVVQQFIRNYPEPLSGEQLSLLSIKYEDFLKALPTIQPTAKREGFATVPD 529

  Fly   480 VEWTDIAGQDVAKQALQEMVILPSVRPELF--TGLRAPAKGLLLFGPPGNGKTLLARAVATECSA 542
            |.|.::......:..|...::.|..||||:  .|:.||. |:||:||||.||||||:|||.|..|
Yeast   530 VTWANVGALQRVRLELNMAIVQPIKRPELYEKVGISAPG-GVLLWGPPGCGKTLLAKAVANESRA 593

  Fly   543 TFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFL 607
            .|::|....|.:||||:.|:.:|.:|..||...|.:||.||:|:|:..|.:|..|:|.|:....|
Yeast   594 NFISIKGPELLNKYVGESERSIRQVFTRARASVPCVIFFDELDALVPRRDTSLSESSSRVVNTLL 658

  Fly   608 VEFDGLPGNPDGDR--IVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQG 668
            .|.|||     .||  |.|:.|||||..:|.|.||  |..|.:::.||:.:.:..::..|.:..|
Yeast   659 TELDGL-----NDRRGIFVIGATNRPDMIDPAMLRPGRLDKSLFIELPNTEEKLDIIKTLTKSHG 718

  Fly   669 SPL----DTEALRRLAKITDGYSGSDLTALAKDAALEPIRE--LNVEQVKCL----------DIS 717
            :||    |.|.:.|..| .:.:||:||.||.:::::..::.  ...|:::.:          |:|
Yeast   719 TPLSSDVDFEEIIRNEK-CNNFSGADLAALVRESSVLALKRKFFQSEEIQSVLDNDLDKEFEDLS 782

  Fly   718 AMRA-----ITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
            ...:     :|..||.|:|::|:.||:.:....|::.::..|
Yeast   783 VGVSGEEIIVTMSDFRSALRKIKPSVSDKDRLKYDRLNKKMG 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	7/31 (23%)
		P-loop_NTPase	482..>538	CDD:304359	25/57 (44%)
		AAA	515..652	CDD:214640	64/140 (46%)
		AAA	519..650	CDD:278434	61/134 (46%)
		Vps4_C	<722..754	CDD:286426	9/31 (29%)
RIX7	NP_013066.1	CDC48	<192..824	CDD:273521	158/560 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810