DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and ATAD1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001308896.1	Gene:	ATAD1 / 84896	HGNCID:	25903	Length:	361	Species:	Homo sapiens

Alignment Length:	293	Identity:	115/293 - (39%)
Similarity:	179/293 - (61%)	Gaps:	19/293 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   456 VSVKGV-----EQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLR-- 513
            :.||.|     |..:...::|.:   ...|.|:||||.|.....|::.||||..:..||...|
Human    62 IGVKNVKLSEYEMSIAAHLVDPL---NMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLL 123

  Fly   514 APAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSI 578
            .|.||:||:||||.||||:|:|.|.|....|:|:..::||.|:.|:.:||..|:|::|..:||||
Human   124 QPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSI 188

  Fly   579 IFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGD---RIVVLAATNRPQELDEAALR 640
            |||||:||.|..||||:|||:..:|.:|:..:|||    |.|   :::|:.||||||:||.|.:|
Human   189 IFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGL----DTDHSCQVIVMGATNRPQDLDSAIMR 249

  Fly   641 RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRE 705
            |...|.:::.|..:.||.:|..:|:.:......:.| .:|:.|||:|||||..:.:||||..:||
Human   250 RMPTRFHINQPALKQREAILKLILKNENVDRHVDLL-EVAQETDGFSGSDLKEMCRDAALLCVRE 313

  Fly   706 -LNVEQVKCLDISAMRAITEQDFHSSLKRIRRS 737
             :|....:..|...:|.:.:||.|.:::::::|
Human   314 YVNSTSEESHDEDEIRPVQQQDLHRAIEKMKKS 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	29/57 (51%)
		AAA	515..652	CDD:214640	67/139 (48%)
		AAA	519..650	CDD:278434	64/133 (48%)
		Vps4_C	<722..754	CDD:286426	4/16 (25%)
ATAD1	NP_001308896.1	RecA-like_ATAD1	92..257	CDD:410928	80/168 (48%)
ATAD1	NP_001308896.1	AAA_lid_3	282..321	CDD:407720	17/39 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810