DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and DAA1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001323399.1	Gene:	DAA1 / 842716	AraportID:	AT1G64110	Length:	829	Species:	Arabidopsis thaliana

Alignment Length:	806	Identity:	230/806 - (28%)
Similarity:	360/806 - (44%)	Gaps:	199/806 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SSSSASSSSTKSPIKSS----SGAGSSGGGLGGRQSTHRSSSASNVAAVVAGGSSAAGGGSSSNR 69
            |.::.|||..:||.:|:    ||..||...|..|:                  .|.|||  :..|
plant   151 SGNTESSSFKRSPSESALEQLSGLFSSFSILPQRE------------------ESKAGG--TLRR 195

  Fly    70 RSPG-----SSPDGDDDTTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSFPI----IFL 125
            :|.|     ||.:|..:        |......|....:....:||.::     ||.|:    .:.
plant   196 QSSGVDIKSSSMEGSSN--------PPKLRRNSSAAANISNLASSSNQ-----VSAPLKRSSSWS 247

  Fly   126 FNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGDGQE 190
            |:. :.|:..|:.:..|:..|:..|:|   .||      |:|.....|::.|...:|       .
plant   248 FDE-KLLVQSLYKVLAYVSKANPIVLY---LRD------VENFLFRSQRTYNLFQKL-------L 295

  Fly   191 QQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISK-ALKIDEENEGHK 254
            |:||.                            |:|....    |..:..|: |.:|||     |
plant   296 QKLSG----------------------------PVLILGS----RIVDLSSEDAQEIDE-----K 323

  Fly   255 ELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFL-ALREQDL--- 315
            ..|:..|...|:..||...:..|.      .:.:|..:.:||.    .:|.|.: .|.|.||
plant   324 LSAVFPYNIDIRPPEDETHLVSWK------SQLERDMNMIQTQ----DNRNHIMEVLSENDLICD 378

  Fly   316 QMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPM----------KLRVRSSGYGPKATTSAQPT 370
            .::.:|.     |:.:.......|.:::.::...|          ||.:.|.......:...:..
plant   379 DLESISF-----EDTKVLSNYIEEIVVSALSYHLMNNKDPEYRNGKLVISSISLSHGFSLFREGK 438

  Fly   371 ASGR-KLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPP 434
            |.|| ||...:|...:..|..:|........|.|:|.: :.:|.|.|          .:.:.||.
plant   439 AGGREKLKQKTKEESSKEVKAESIKPETKTESVTTVSS-KEEPEKEA----------KAEKVTPK 492

  Fly   435 QRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLIL--DEIVEGGAKVEWTDIAGQDVAKQALQE 497
            .....|.|.                 .|:::...::  :||     .|.:.||...|..|::|||
plant   493 APEVAPDNE-----------------FEKRIRPEVIPAEEI-----NVTFKDIGALDEIKESLQE 535

  Fly   498 MVILPSVRPELFT-GLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGE 561
            :|:||..||:||| ||..|.:|:|||||||.|||:||:|:|.|..|:|:|:|.:::|||:.|:.|
plant   536 LVMLPLRRPDLFTGGLLKPCRGILLFGPPGTGKTMLAKAIAKEAGASFINVSMSTITSKWFGEDE 600

  Fly   562 KLVRALFAVARHMQPSIIFIDEVDSLLSERSS-SEHEASRRLKTEFLVEFDGLPGNPDGDRIVVL 625
            |.|||||.:|..:.|:|||:|||||:|.:|:. .||||.|::|.||:..:|||...| |:||:||
plant   601 KNVRALFTLASKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFMSHWDGLMTKP-GERILVL 664

  Fly   626 AATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQ--GSPLDTEALRRLAKITDGYSG 688
            ||||||.:||||.:|||.:|:.|.||..:.||.:|..||.|:  ...||   .:.||.:|:||:|
plant   665 AATNRPFDLDEAIIRRFERRIMVGLPAVENREKILRTLLAKEKVDENLD---YKELAMMTEGYTG 726

  Fly   689 SDLTALAKDAALEPIRELNVEQVKCLD----------------------ISAMRAITEQDFHSSL 731
            |||..|...||..|:||| ::|.:..|                      :..:|.:..|||..:.
plant   727 SDLKNLCTTAAYRPVREL-IQQERIKDTEKKKQREPTKAGEEDEGKEERVITLRPLNRQDFKEAK 790

  Fly   732 KRIRRSVAPQ--SLNSYEKWSQDYGD 755
            .::..|.|.:  .:...::|::.||:
plant   791 NQVAASFAAEGAGMGELKQWNELYGE 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	18/78 (23%)
		P-loop_NTPase	482..>538	CDD:304359	32/56 (57%)
		AAA	515..652	CDD:214640	77/137 (56%)
		AAA	519..650	CDD:278434	74/131 (56%)
		Vps4_C	<722..754	CDD:286426	6/33 (18%)
DAA1	NP_001323399.1	P-loop_NTPase	522..687	CDD:422963	92/165 (56%)
DAA1	NP_001323399.1	AAA_lid_3	711..755	CDD:407720	20/47 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810