DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and AT1G62130

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_176404.3	Gene:	AT1G62130 / 842509	AraportID:	AT1G62130	Length:	1043	Species:	Arabidopsis thaliana

Alignment Length:	758	Identity:	196/758 - (25%)
Similarity:	321/758 - (42%)	Gaps:	176/758 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 YGGYSSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQN 167
            |..|:|.:...|      |.|.|.....|.|||             :::.:......|.::::.:
plant   344 YAPYASDLTILN------PRILLSGPAGSEIYQ-------------EILAKALANSFNAKLLIFD 389

  Fly   168 S--------SKEQQQSLNHPSELNR---------EGDGQEQQLSNQPQRF-RPIQPL-------E 207
            |        :||.:..:|.|:.::|         :||......:..|:.| .||..|       .
plant   390 SNPILGVMTAKEFESLMNGPALIDRGKSLDLSSGQGDSSIPSPATSPRSFGTPISGLLILHWGKT 454

  Fly   208 MAANR---------PGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRK 263
            :|.:|         ||...|.||              .:.:|.|.|.:.:||...|        .
plant   455 LAGDRVRFFGDELCPGLPTSRGP--------------PYGFIGKVLLVFDENPSAK--------V 497

  Fly   264 GIK---ELEDGIAVD--CWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDL-QMQRLSL 322
            |::   .:.||:.:.  |..|.|               ....|.| |.|.:....|| ::....|
plant   498 GVRFENPVPDGVDLGQLCEMGHG---------------FFCSATD-LQFESSASDDLNELLVTKL 546

  Fly   323 KEKQKEEAQSKP----QKTREPMLAGMTN----EPMKLRVRSSGYGP--KATTSAQPTASG---- 373
            .|...:::::.|    .|..|....|.::    ...||.|.|.....  ..|.|..|...|
plant   547 FEVAHDQSRTCPVIIFLKDAEKYFVGNSHFCSAFKSKLEVISDNLIVICSQTHSDNPKEKGIGRL 611

  Fly   374 -----RKLTIGSKRPVNLAVANK------SQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFS 427
                 .|:||...:...|..:.|      ::||............:.|...:.........:..:
plant   612 TDLFVNKVTIYMPQGEELLKSWKYHLDRDAETLKMKANYNHLRMVLGRCGIECEGIETLCMKDLT 676

  Fly   428 SGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQ-----KLVQL----------------ILD 471
            ..|::..:.....::::..|..||...|..:..:|.     :|:::                |.|
plant   677 LRRDSAEKIIGWALSHHIKSNPGADPDVRVILSLESLKCGIELLEIESKKSLKDIVTENTFEISD 741

  Fly   472 EIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFT--GLRAPAKGLLLFGPPGNGKTLLAR 534
            .|......|.:.||...:..|..|:|:|:||...||||.  .|..|..|:|||||.|.|||:||:
plant   742 IIPPSEIGVTFDDIGALENVKDTLKELVMLPFQWPELFCKGQLTKPCNGILLFGPSGTGKTMLAK 806

  Fly   535 AVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEAS 599
            |||||..|..:|:|    .|::..:|||.|:|:|::|..:.|||||:|||:|:|       |...
plant   807 AVATEAGANLINMS----MSRWFSEGEKYVKAVFSLASKISPSIIFLDEVESML-------HRYR 860

  Fly   600 RRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLL 664
            .:.|.||::.:|||..| :.:|::||||||||.:||||.:||...|:.|.|||.::|..:|..:|
plant   861 LKTKNEFIINWDGLRTN-EKERVLVLAATNRPFDLDEAVIRRLPHRLMVGLPDARSRSKILKVIL 924

  Fly   665 QKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISA----------- 718
            .|:....|.: :..:|.:|:||||:||..|...||...|.|: ||:.|....:|
plant   925 SKEDLSPDFD-IDEVASMTNGYSGNDLKNLCVTAARRRIIEI-VEKEKSERDAAVAEGRVPPAGS 987

  Fly   719 ----MRAITEQDFHSSLKRIRRSVAPQSLN--SYEKWSQDYGD 755
                :|.:..:||.::|:.:..|::.:|:|  :..:|::|||:
plant   988 GGSDLRVLKMEDFRNALELVSMSISSKSVNMTALRQWNEDYGE 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	15/82 (18%)
		P-loop_NTPase	482..>538	CDD:304359	28/57 (49%)
		AAA	515..652	CDD:214640	65/136 (48%)
		AAA	519..650	CDD:278434	62/130 (48%)
		Vps4_C	<722..754	CDD:286426	8/33 (24%)
AT1G62130	NP_176404.3	P-loop_NTPase	749..>816	CDD:304359	33/66 (50%)
		AAA	789..912	CDD:214640	64/134 (48%)
		AAA	791..910	CDD:278434	62/130 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810