DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and FTSH1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_564563.1	Gene:	FTSH1 / 841447	AraportID:	AT1G50250	Length:	716	Species:	Arabidopsis thaliana

Alignment Length:	502	Identity:	135/502 - (26%)
Similarity:	201/502 - (40%)	Gaps:	107/502 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 QMQRLSLKEKQKEEAQSKPQKTREP----MLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKL 376
            |:.|.|..|.......:.|..::..    :|:.:::.|:.|.|......|.....:|........
plant    45 QITRSSQDENSPNGKPNSPFSSQVALAAILLSSISSSPLALAVVDEPASPSVVIESQAVKPSTPS 109

  Fly   377 TIGSKRPVNLAVANKSQTLPRNL------------------------GSKTSVGAV-QRQPAKTA 416
            .:..:..:..|.:.||..||...                        ||...:.|| .|:.:...
plant   110 PLFIQNEILKAPSPKSSDLPEGSQWRYSEFLNAVKKGKVERVRFSKDGSVVQLTAVDNRRASVIV 174

  Fly   417 ATPP-------------AVRRQFSSGRNTPPQRSRTPINN-----------------------NG 445
            ...|             :|....|||.:.     .|.|.|                       .|
plant   175 PNDPDLIDILAMNGVDISVSEGESSGNDL-----FTVIGNLIFPLLAFGGLFLLFRRAQGGPGGG 234

  Fly   446 PSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFT 510
            |.|.|........|...|        |:.|.|  |.:.|:||.|.||..|||:|.... .|:.:|
plant   235 PGGLGGPMDFGRSKSKFQ--------EVPETG--VSFADVAGADQAKLELQEVVDFLK-NPDKYT 288

  Fly   511 GLRAP-AKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHM 574
            .|.|. .||.||.||||.||||||||||.|....|.:.:|:.....:||.|...||.||..|:..
plant   289 ALGAKIPKGCLLVGPPGTGKTLLARAVAGEAGVPFFSCAASEFVELFVGVGASRVRDLFEKAKSK 353

  Fly   575 QPSIIFIDEVDSLLSERSS---SEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDE 636
            .|.|:||||:|::..:|.:   ..::...:...:.|.|.||..||   ..::||||||||..||.
plant   354 APCIVFIDEIDAVGRQRGAGMGGGNDEREQTINQLLTEMDGFSGN---SGVIVLAATNRPDVLDS 415

  Fly   637 AALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEA-LRRLAKITDGYSGSDLTALAKDA 698
            |.||  ||.::|.|..||...|..:|.  :..:|..|..:. ..::|:.|.|::|:||..|..:|
plant   416 ALLRPGRFDRQVTVDRPDVAGRVKILQ--VHSRGKALGKDVDFDKVARRTPGFTGADLQNLMNEA 478

  Fly   699 ALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNS 745
            |:...|.            .::.|::.:...:|:||  ...|:..|:
plant   479 AILAARR------------ELKEISKDEISDALERI--IAGPEKKNA 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	31/56 (55%)
		AAA	515..652	CDD:214640	60/142 (42%)
		AAA	519..650	CDD:278434	58/135 (43%)
		Vps4_C	<722..754	CDD:286426	6/24 (25%)
FTSH1	NP_564563.1	FtsH_fam	242..706	CDD:273520	102/300 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910