Protein Alignment spas and KATNAL2

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001340828.1
• Gene: KATNAL2 / 83473
• HGNCID: 25387
• Length: 564
• Species: Homo sapiens
• Alignment Length: 584
• Identity: 176/584 - (30%)
• Similarity: 275/584 - (47%)
• Gaps: 109/584 - (18%)

  Fly   228 KQKHHHRRAFE----------------YISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDC 276
            |..|..|.|.|                |:::...||..|...:|..:.|.|   .|:.|.|.::
Human    35 KFTHQAREACEMRTEARRKNLLILISHYLTQEGYIDTANALEQETKLGLRR---FEVCDNIDLE- 95

  Fly   277 WSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSK-PQ----K 336
                                .:.|..:..:|:..::..      .:.:|..:.|::. ||    |
Human    96 --------------------TILMEYESYYFVKFQKYP------KIVKKSSDTAENNLPQRSRGK 134

  Fly   337 TREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGS 401
            ||..|.....|.|...:.|     |::.|:|..|...:.|   :|...|..|.:.::....|.|
Human   135 TRRMMNDSCQNLPKINQQR-----PRSKTTAGKTGDTKSL---NKEHPNQEVVDNTRLESANFG- 190

  Fly   402 KTSVGAVQRQPAKTAATP-------------PAVRRQFSS-GRNT------PPQRSRTPINNNGP 446
             ..:..:::...:..|.|             .|::...|. ..||      |.:|...|:
Human   191 -LHISRIRKDSGEENAHPRRGQIIDFQGLLTDAIKGATSELALNTFDHNPDPSERLLKPL----- 249

  Fly   447 SGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTG 511
                  :..:.:....::|..::..:|......::|.||.|.|.|||.::|.|:.|...|:||||
Human   250 ------SAFIGMNSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTG 308

  Fly   512 LRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQP 576
            :.:|.|||||:||||.||||||:||||||..||.||||:::.||:.||.|||||.||.:||:..|
Human   309 ILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAP 373

  Fly   577 SIIFIDEVDSLLSER---SSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAA 638
            |.||:||::|::|:|   |..|||.|.|:|||.||:.|||..:.  |.:.||||:|.|.|||.|.
Human   374 STIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSE--DLVFVLAASNLPWELDCAM 436

  Fly   639 LRRFTKRVYVSLPDEQTRELLLNRLL----QKQGSPLDTE-ALRRLAKITDGYSGSDLTALAKDA 698
            |||..||:.|.||..:.|:.::...|    :.:...|.|| ....|::.|:||||||:..:.::|
Human   437 LRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREA 501

  Fly   699 ALEPIRE----LNVEQVKCLDISAMR--AITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYGDI 756
            |:.|:|:    |...|.:..|:..::  .:|..||...|...:.| |......|..|.:::..:
Human   502 AMRPVRKIFDALENHQSESSDLPRIQLDIVTTADFLDVLTHTKPS-AKNLAQRYSDWQREFESV 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	15/93 (16%)
		P-loop_NTPase	482..>538	CDD:304359	34/55 (62%)
		AAA	515..652	CDD:214640	82/139 (59%)
		AAA	519..650	CDD:278434	78/133 (59%)
		Vps4_C	<722..754	CDD:286426	8/31 (26%)
KATNAL2	NP_001340828.1	LisH	51..81	CDD:128913	5/29 (17%)
		SpoVK	<264..559	CDD:223540	128/297 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910