DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and AtCDC48C

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_568114.1	Gene:	AtCDC48C / 831870	AraportID:	AT5G03340	Length:	810	Species:	Arabidopsis thaliana

Alignment Length:	619	Identity:	162/619 - (26%)
Similarity:	250/619 - (40%)	Gaps:	148/619 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 PQRFRPIQPLEMAANRPGGGY----SPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELA 257
            ||.|:.|      ..:|..|.    .||.|..|:|:...:...||.:.....:|..:..|..|..
plant   230 PQLFKSI------GVKPPKGILLYGPPGSGKTLIARAVANETGAFFFCINGPEIMSKLAGESESN 288

  Fly   258 IELYRKGIKELE------------DGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLAL 310
            :   ||..:|.|            |.||.......|:|   .:|:..::.|.:...:.|.|.:.:
plant   289 L---RKAFEEAEKNAPSIIFIDEIDSIAPKREKTNGEV---ERRIVSQLLTLMDGLKSRAHVIVM 347

  Fly   311 REQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKL--RVRSSGYGPKATTSAQPTASG 373
                                             |.||.|..:  .:|..|...:......|...|
plant   348 ---------------------------------GATNRPNSIDPALRRFGRFDREIDIGVPDEIG 379

  Fly   374 RKLTIGSKRPVNLAVANKSQTLPRNLG----SKTSVGAVQRQPAK--TAATPPAVRRQFS----- 427
            | |.:       |.:..|:..|..::.    ||.:.|.|....|.  |.|....:|.:..
plant   380 R-LEV-------LRIHTKNMKLAEDVDLERISKDTHGYVGADLAALCTEAALQCIREKMDVIDLE 436

  Fly   428 ---------SGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWT 483
                     :......:...|.:.|:.||.                     |.|.|.....|.|.
plant   437 DDSIDAEILNSMAVSNEHFHTALGNSNPSA---------------------LRETVVEVPNVSWE 480

  Fly   484 DIAGQDVAKQALQEMVILPSVRPELFT--GLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLN 546
            ||.|.:..|:.|||.|..|...||.|.  |: :|:||:|.:||||.||||||:|:|.||.|.|::
plant   481 DIGGLENVKRELQETVQYPVEHPEKFEKFGM-SPSKGVLFYGPPGCGKTLLAKAIANECQANFIS 544

  Fly   547 ISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHE---ASRRLKTEFLV 608
            :....|.:.:.|:.|..||.:|..||...|.::|.||:||:.::|.:|..:   |:.|:..:.|.
plant   545 VKGPELLTMWFGESEANVREIFDKARQSAPCVLFFDELDSIATQRGNSAGDAGGAADRVLNQLLT 609

  Fly   609 EFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPL 671
            |.||:...   ..:.::.|||||..:|.|.||  |..:.:|:.||||.:|..:....|:|.....
plant   610 EMDGMNAK---KTVFIIGATNRPDIIDSALLRPGRLDQLIYIPLPDEDSRLNIFKACLRKSPVAK 671

  Fly   672 DTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMR------AITEQD---- 726
            |.: :..|||.|.|:||:|:|.:.:.|....||| |:|:    ||...|      ...|:|
plant   672 DVD-VTALAKYTQGFSGADITEICQRACKYAIRE-NIEK----DIENERRRSQNPEAMEEDMVDD 730

  Fly   727 ---------FHSSLKRIRRSVAPQSLNSYEKWSQ 751
                     |..|:|..||||:...:..|:.::|
plant   731 EVSEIRAAHFEESMKYARRSVSDADIRKYQAFAQ 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	18/89 (20%)
		P-loop_NTPase	482..>538	CDD:304359	29/57 (51%)
		AAA	515..652	CDD:214640	54/141 (38%)
		AAA	519..650	CDD:278434	50/135 (37%)
		Vps4_C	<722..754	CDD:286426	11/43 (26%)
AtCDC48C	NP_568114.1	CDC48	29..768	CDD:273521	162/619 (26%)
		CDC48_N	29..111	CDD:280513
		CDC48_2	135..195	CDD:215011
		AAA	244..374	CDD:278434	29/168 (17%)
		AAA	517..650	CDD:278434	50/135 (37%)
		Vps4_C	720..764	CDD:286426	10/43 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810