DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and AT3G24530

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_566752.1	Gene:	AT3G24530 / 822048	AraportID:	AT3G24530	Length:	481	Species:	Arabidopsis thaliana

Alignment Length:	523	Identity:	108/523 - (20%)
Similarity:	187/523 - (35%)	Gaps:	132/523 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 QRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPM--LAGMTN-EP 349
            |||.....|.       :|..||....:.:||| ||:......:..|.....|:  .||..| :.
plant     9 QRLRSARPTT-------IHDCALSGDLIALQRL-LKDNPSLLNERNPVMYHTPLHVSAGNGNVDI 65

  Fly   350 MKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAV-------------ANKSQTLPRNLGS 401
            :|..:..:| ..|....|..|.....|.:.:|...|.|.             |:...| |.:|..
plant    66 VKYLLAWTG-SDKVELEAMNTYGETPLHMAAKNGCNEAAKLLLESGAFIEAKASNGMT-PLHLAV 128

  Fly   402 KTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLV 466
            ..|:.|.:....||..       ..::..:.......||:::. |.|.|:           :||.
plant   129 WYSITAKEISTVKTLL-------DHNADCSAKDNEGMTPLDHL-PQGQGS-----------EKLR 174

  Fly   467 QLI------------LDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGL 519
            :|:            |::..:..||:|        :.:..|..:|.|    .||.|.||..|||:
plant   175 ELLRWFLQEQRKRSALEQCGKTKAKME--------LLEDELSNIVGL----SELKTQLRKWAKGM 227

  Fly   520 LL---------------------FGPPGNGKTLLARAVATECSATFL-------NISAASLTSKY 556
            ||                     .|.||.|||::||.:....:...:       .:....|..::
plant   228 LLDERRRALGLNIGTRRPPHMAFLGNPGTGKTMVARVLGKLLNTVGILPTDKVTEVQRTDLVGEF 292

  Fly   557 VG-DGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGD 620
            || .|.|..|.:    :..:..|:|:||...|:..:.:.:.:.......|.:...|      .|.
plant   293 VGHTGPKTRRKI----QEAEGGILFVDEAYRLIPMQKADDKDYGLEALEEIMSVMD------TGK 347

  Fly   621 RIVVLAATNRPQE----LDEAALRRFTKRVYVSLPDEQTREL--LLNRLLQKQGSPL-------- 671
            .:|:.|..:.|.:    .:|...||.||  :.:..|...:||  :|:..:..||...
plant   348 IVVIFAGYSEPMKRVIASNEGFCRRVTK--FFNFSDFSAKELAQILHIKMNNQGEDTLFYGFRLH 410

  Fly   672 DTEALRRLAKI----TDGYSGSDLTALAKDAALEPIRELNVE---QVKCLDISAMRAITEQDFHS 729
            ::..|:.:|.:    |......::.....|..|...|| |::   ..:|:|...:..|..:|..:
plant   411 ESCTLQEIASLIEAETTEKQRKEMNGGLVDTLLVNARE-NLDLRLSFECVDTEEICTIKLEDLEA 474

  Fly   730 SLK 732
            .|:
plant   475 GLR 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	5/19 (26%)
		P-loop_NTPase	482..>538	CDD:304359	21/76 (28%)
		AAA	515..652	CDD:214640	35/169 (21%)
		AAA	519..650	CDD:278434	32/163 (20%)
		Vps4_C	<722..754	CDD:286426	3/11 (27%)
AT3G24530	NP_566752.1	Ank_2	19..116	CDD:403870	22/98 (22%)
		ANK repeat	51..84	CDD:293786	8/33 (24%)
		ANK repeat	86..117	CDD:293786	4/30 (13%)
		Ank_2	91..177	CDD:403870	19/105 (18%)
		ANK repeat	119..154	CDD:293786	7/42 (17%)
		P-loop_NTPase	191..>398	CDD:422963	50/230 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900