DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and AT3G19740

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_188608.4	Gene:	AT3G19740 / 821511	AraportID:	AT3G19740	Length:	993	Species:	Arabidopsis thaliana

Alignment Length:	863	Identity:	230/863 - (26%)
Similarity:	364/863 - (42%)	Gaps:	189/863 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VRTKNQSSSSSASSSSTKSPIKSSSGAGSSGGGLGGRQSTHRSSSASNVAAVVAGGSSAA----G 62
            :|.||.:|...|...|:...|...|..|:.   |...:.....:....|..:|...|..|    .
plant   200 IRQKNAASIYGARLDSSSGRILLQSVPGTE---LYRERLVRALARDVQVPLLVLDSSVLAPYDFA 261

  Fly    63 GGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSFPIIFLFN 127
            ...:....|.|.:.:.:.|.:||:.......|.:|..........|...:..|.|..       .
plant   262 DDYNEESESDGENAEAEADESTTESDAEEDSSAQSEEDSEAKADGSDSEEACLEVSE-------E 319

  Fly   128 VLRSLIYQL----FCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLN-------HPSE 181
            .::.::.:|    ..:...|:|.:.:.            ..|::|.|.::.:..       .||
plant   320 AIKKIVPKLEEFEKLVAEELHGEACEA------------AAVEHSDKARRPAKKGDRVKYVGPS- 371

  Fly   182 LNREGDGQEQQLSNQPQRFRPIQPLEMAANRP------GGGYSPGPGDPLLAKQKHHHRRAFEYI 240
              ::.|.:.:.||:..:.    :..|:..||.      ||..|...||.  ...:|.|:....:|
plant   372 --KKADAKHRPLSSGQRG----EVYEVNGNRVAVIFDIGGDTSSEGGDK--KSTEHSHKLHMHWI 428

  Fly   241 SKA-LKID---EENEGHKELAIELYRKGIKELEDGIAV----DCW-------SGRGDVWDRAQRL 290
            ... ||.|   :..:|:  :|:|...:.:...:..|..    ..|       |.:.:..|:.|.:
plant   429 DVGDLKHDLDMQAEDGY--IALEALSEVLHSTQPLIVYFPDSSQWLSRAVPKSKQNEFVDKVQEM 491

  Fly   291 HDKMQTNLSM----------ARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGM 345
            .||:.:.:.|          :::|..|..:.....::.:|.|..|:..|..: .:||.|
plant   492 FDKLSSPVVMICGRNKIETGSKEREKFTMILPNFGRLAKLPLPLKRLTEGLT-GRKTSE------ 549

  Fly   346 TNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANK------------------- 391
            .||..||........|                  .|...||.|.||
plant   550 DNEIYKLFTNVMNLVP------------------PKEEENLIVFNKQLGEDRRIVMSRSNLNELL 596

  Fly   392 -----SQTLPRNLGSKTSVGAV-QRQPAK-----------TAATPPAVRRQFSSGRNTPPQRSRT 439
                 ::.|..:|....:.|.: .:|.|:           ::...|:::    .||...|:.|..
plant   597 KALEENELLCTDLYQVNTDGVILTKQRAEKVIGWARNHYLSSCPSPSIK----EGRLILPRESIE 657

  Fly   440 PINNNGPSGSGASTPVVSVKGVE----------QKLVQLILDE---------IVEGGAKVEWTDI 485
                            :|||.::          |.|..:..||         :..|...|::.||
plant   658 ----------------ISVKRLKAQEDISRKPTQNLKNIAKDEFETNFVSAVVAPGEIGVKFDDI 706

  Fly   486 AGQDVAKQALQEMVILPSVRPELFT--GLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNIS 548
            ...:..|:.|.|:||||..||||||  .|..|.||:|||||||.||||||:|:|||..|.|::|:
plant   707 GALEHVKKTLNELVILPMRRPELFTRGNLLRPCKGILLFGPPGTGKTLLAKALATEAGANFISIT 771

  Fly   549 AASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSS-EHEASRRLKTEFLVEFDG 612
            .::||||:.||.|||.:|||:.|..:.|.|||:|||||||..|..: ||||:||::.||:..:||
plant   772 GSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEHEATRRMRNEFMAAWDG 836

  Fly   613 LPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALR 677
            | .:.|..||::|.|||||.:||:|.:||..:|:||.|||.:.|..:|...|..:......| ..
plant   837 L-RSKDSQRILILGATNRPFDLDDAVIRRLPRRIYVDLPDAENRLKILKIFLTPENLETGFE-FD 899

  Fly   678 RLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISA---MRAITEQDFHSSLKRIRRSVA 739
            :|||.|:|||||||..|...||..|::||..|:.|....:|   :|.::..||..|..::..|||
plant   900 KLAKETEGYSGSDLKNLCIAAAYRPVQELLQEENKDSVTNASPDLRPLSLDDFIQSKAKVSPSVA 964

  Fly   740 --PQSLNSYEKWSQDYGD 755
              ..::|...||::.||:
plant   965 YDATTMNELRKWNEQYGE 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	18/102 (18%)
		P-loop_NTPase	482..>538	CDD:304359	33/57 (58%)
		AAA	515..652	CDD:214640	77/137 (56%)
		AAA	519..650	CDD:278434	73/131 (56%)
		Vps4_C	<722..754	CDD:286426	9/33 (27%)
AT3G19740	NP_188608.4	SDA1	<259..>363	CDD:283052	16/122 (13%)
		AAA	740..875	CDD:214640	76/135 (56%)
		AAA	742..873	CDD:278434	73/131 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810