DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and AT2G45500

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001323445.1	Gene:	AT2G45500 / 819158	AraportID:	AT2G45500	Length:	497	Species:	Arabidopsis thaliana

Alignment Length:	528	Identity:	200/528 - (37%)
Similarity:	286/528 - (54%)	Gaps:	99/528 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 EYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDV---WDRAQRLHDKMQTNLS 299
            |.|:..||      |:.:||.|...||::..|       |....|.   :..|||:.::..:..|
plant    56 ERIAYKLK------GYFDLAKEEIAKGVRAEE-------WGLHDDALLHYRNAQRIMNEATSTPS 107

  Fly   300 MARDRLHFLALREQDLQMQRLSLKEKQKEEA--------QSKPQKTREPMLAGMTNEPMKLRVRS 356
            .:                 .:|..||:|..:        |::..:..:.:..||:...     |:
plant   108 PS-----------------YISSSEKEKVRSYREKISNWQNQVSERLQALGVGMSENK-----RT 150

  Fly   357 SGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPA 421
            ..|...|:.|:  |||..:.|:..|.|    ||......|||             |...||:|
plant   151 VAYPSSASVSS--TASRYRKTLSQKTP----VARGGVATPRN-------------PKDAAASP-- 194

  Fly   422 VRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIA 486
                             .|:..:|             ...:.|||::|...||:....|:|.|:|
plant   195 -----------------KPVKESG-------------NVYDDKLVEMINTTIVDRSPSVKWDDVA 229

  Fly   487 GQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAAS 551
            |.:.|||||.||||||:.|.:||||||.||:|||||||||||||:||:|||:|..|||.|:||:|
plant   230 GLNGAKQALLEMVILPAKRRDLFTGLRRPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASS 294

  Fly   552 LTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGN 616
            ||||:||:.||||:.||.||...|||:||:||:||::|.||:||:|||||||:|||::|||:..|
plant   295 LTSKWVGEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVTSN 359

  Fly   617 PDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAK 681
            || |.::::.|||:|||||:|.|||..||:||.|||...|:||....|:.|...|....:.::.|
plant   360 PD-DLVIIIGATNKPQELDDAVLRRLVKRIYVPLPDSNVRKLLFKTKLKCQPHSLSDGDIDKIVK 423

  Fly   682 ITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSY 746
            .|:|||||||.||.::||:.|||||.. .:..:..:.:|::...||..|:..||.|::.......
plant   424 ETEGYSGSDLQALCEEAAMMPIRELGA-NILTIQANKVRSLRYDDFRKSMAVIRPSLSKSKWEEL 487

  Fly   747 EKWSQDYG 754
            |:|:.::|
plant   488 ERWNSEFG 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	17/72 (24%)
		P-loop_NTPase	482..>538	CDD:304359	41/55 (75%)
		AAA	515..652	CDD:214640	90/136 (66%)
		AAA	519..650	CDD:278434	86/130 (66%)
		Vps4_C	<722..754	CDD:286426	8/31 (26%)
AT2G45500	NP_001323445.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	181	1.000	Domainoid score	I1040
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8970
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	1	1.000	-	-		otm40245
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	1	1.100	-	-	LDO	PTHR23074
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3342
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.780