DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and pex1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001164306.1	Gene:	pex1 / 793906	ZFINID:	ZDB-GENE-070530-1	Length:	1237	Species:	Danio rerio

Alignment Length:	909	Identity:	204/909 - (22%)
Similarity:	312/909 - (34%)	Gaps:	304/909 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SSSSSASSSSTKSPIKSSSGAGSSGG-----GL------GGRQSTHRSSSASNVAAVVAGGSSAA 61
            |||.|.:|..:::....|...|..||     ||      .||:......:...:.|::
Zfish   198 SSSISNASQDSQNDHPESLNEGHWGGIADLKGLVRYLFTRGREPAKEKIAVPTIPAIL------- 255

  Fly    62 GGGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCS--PRSGHHHSYGGYSSSVH--------KQNLY 116
                                    .|....||.  |||..||  |.....||        ::|
Zfish   256 ------------------------KDCILRTCGSPPRSVSHH--GSCHGDVHILPWNLQEQEN-- 292

  Fly   117 VVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNH--- 178
                     :|..:|.:         .||..:|::.....|    |.|.|...|::.:..:|
Zfish   293 ---------WNPGQSAL---------TYGRLSKILSPKELR----EKVKQAMEKKKIRDASHKEK 335

  Fly   179 PSELNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKA 243
            .:|.:.|.....:.|.:...|.:..|.|    |:....||   |...:.|.          :.:.
Zfish   336 DTEEHMENSAVVRMLCHNINRLQEDQKL----NKCEEIYS---GKIWIPKM----------LQRR 383

  Fly   244 LKIDEEN--------------------------EGHKELAIELYRKGIKELEDGIAVDCWSGRGD 282
            ||||..:                          |..||..|::......:.:....:.|.:||.:
Zfish   384 LKIDLHSAVRIQPLKSMPRLAETVMVQPLQPLAESEKEEDIQMAFLNWFDAQSHQPLTCLTGRSN 448

  Fly   283 V--WDRAQRLHDKMQTNL---SMARDRLHFLA---LREQDLQMQR-------------------- 319
            :  ...|:...:...|.|   ....|.|.||:   ||:.|:|:.|
Zfish   449 IILLPCAEGKEEFALTVLKPEQQQEDELFFLSNSLLRKTDIQIAREPHNSDHRGSDNDTEDQCLG 513

  Fly   320 ---LSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSK 381
               ||.....::.::|..|.....:|.|    .:...:.|:|.|.:........|.|     ..|
Zfish   514 FPSLSSLGGVEDISRSAFQHISHALLGG----SLSRELISTGRGLRGGALLITGAKG-----SGK 569

  Fly   382 RPVNLAVANK-SQTLPRN---LGSKTSVG----------------AVQRQPAKT----------A 416
            ..::.|:..| |:.|..:   |..||..|                ||.|||:..          |
Zfish   570 SSLSRALCRKASEDLDAHIQLLDCKTLKGKRTDTIRQRLEDVFEQAVWRQPSVVLLDDLDHVAGA 634

  Fly   417 AT-------PPAVRRQFSS-------------------------------------GRN------ 431
            ||       |.||.||..|                                     |.:
Zfish   635 ATSPEHEHGPEAVLRQHISQSLKDLVDEIVLRSSLIALIVTAQTEHALHPTLTVVQGSHFFQSFC 699

  Fly   432 ---TPPQRSRTPINNN---GPSGSGASTPV------VSVKGVEQKLVQLILDEIVE--------- 475
               ||.|..|..|..:   ..|.....|.:      ...:|...:.:.|:|:..:.
Zfish   700 KIPTPDQAQRVEILKSLIVKKSFQVCQTTLDLDSVAKETEGFMARDLNLLLERAIHANTLHNSED 764

  Fly   476 --------------------------GGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRA 514
                                      .||.:|  .|.|...|:|.|.::::||:..|.||:.|
Zfish   765 LSCKDFRQALQGFTPPSLWDAQLQAPSGAGME--RIGGLHEARQLLMDIILLPAKYPLLFSSL-- 825

  Fly   515 PAK---GLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQP 576
            |.:   |:||:|.||.||||||.|||.|....|::|....|.|||:|..|:.||.:|..|:..:|
Zfish   826 PLRQCSGVLLYGAPGTGKTLLAGAVAKESGMNFISIKGPELLSKYIGASEQAVRDVFQRAQQAKP 890

  Fly   577 SIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR- 640
            .|:|.||.|||...|.......:.|:..:.|.:.||:.|...   :.||||::||..:|.|.||
Zfish   891 CILFFDEFDSLAPRRGHDNTGVTDRVVNQLLTQLDGVEGLTG---VYVLAASSRPDLIDPALLRP 952

  Fly   641 -RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPI 703
             |..|.:|...||.:.|..:|..|........|.: |.::|..|:.::|:||.||..:|.||.|
Zfish   953 GRLDKSLYCPPPDREARLEILRALTHSVPLAADVD-LDQIAGATELFTGADLKALLYNAQLEAI 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	16/108 (15%)
		P-loop_NTPase	482..>538	CDD:304359	26/58 (45%)
		AAA	515..652	CDD:214640	56/141 (40%)
		AAA	519..650	CDD:278434	54/132 (41%)
		Vps4_C	<722..754	CDD:286426
pex1	NP_001164306.1	PEX-2N	12..89	CDD:286362
		PEX-1N	101..171	CDD:286361
		SpoVK	559..1026	CDD:223540	124/470 (26%)
		P-loop_NTPase	559..686	CDD:304359	25/131 (19%)
		AAA	833..962	CDD:278434	54/131 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000