DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and SPATA5L1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_076968.2	Gene:	SPATA5L1 / 79029	HGNCID:	28762	Length:	753	Species:	Homo sapiens

Alignment Length:	623	Identity:	170/623 - (27%)
Similarity:	262/623 - (42%)	Gaps:	133/623 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 GQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPL--LAKQKHHHRRAFEYISKA-----LK 245
            |.|.....|||   |..||        ||.|.. .|.|  |.:....:.||...:..|     |.
Human   187 GGEPPSEAQPQ---PEVPL--------GGLSEA-ADSLRELLRLPLRYPRALTALGLAVPRGVLL 239

  Fly   246 IDEENEGHKELAIELYRKGIKELEDGIAVDC----WSGRGDVWDRAQRLHDKMQTNLSMARDRLH 306
            ......|..:|...:.|:...||   :||..    .|..|:..:..:|:..:.:   .:|.....
Human   240 AGPPGVGKTQLVRAVAREAGAEL---LAVSAPALQGSRPGETEENVRRVFQRAR---ELASRGPS 298

  Fly   307 FLALREQD-LQMQRLSLKEKQKEEAQ-----SKPQKTREPMLAGMTNEPMKL--RVRSSGYGPKA 363
            .|.|.|.| |..||.|...:.:..||     ......||.::.|.||.|..|  .:|..|...:.
Human   299 LLFLDEMDALCPQRGSRAPESRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDRE 363

  Fly   364 TTSAQPTASGRK---LTIGSKRPVNLAVANKSQTLPRNLG--SKTSVG-------AVQRQPA--- 413
            .....||...||   ..|.||.|::..|         :||  ::.:||       |:.|:.|
Human   364 VVIGTPTLKQRKEILQVITSKMPISSHV---------DLGLLAEMTVGYVGADLTALCREAAMHA 419

  Fly   414 -----KTAATPPAVRRQF-SSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDE 472
                 |....|......| .:.:|..|...|:.|.            ::.:|
Human   420 LLHSEKNQDNPVIDEIDFLEAFKNIQPSSFRSVIG------------LMDIK------------- 459

  Fly   473 IVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFT--GLRAPAKGLLLFGPPGNGKTLLARA 535
                  .|:|.:|.|.:..|..|::.:..|...|..|.  ||..| ||:||:||||..||.|.||
Human   460 ------PVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQP-KGVLLYGPPGCAKTTLVRA 517

  Fly   536 VATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEH--EA 598
            :||.|..:|:::|.|.|.|.:|||.||::..:|..||...|:|:|:||:||:|..||:|:.  :.
Human   518 LATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDV 582

  Fly   599 SRRLKTEFLVEFDGL-------PGNPDGDR---------IVVLAATNRPQELDEAALR--RFTKR 645
            ..|:.:..|.|.||:       .|:....:         ::::||||||..||.|.||  |..|.
Human   583 QERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKI 647

  Fly   646 VYVSLPDEQTRELLLNRLLQKQGSPLDTE-ALRRLAKITDGYSGSDLTALAKDAALEPIRELNVE 709
            :|:..||.:.|..:|.  :..:..|:..: :|..||..|..:||:||..|..:|||..::|..::
Human   648 IYIPPPDHKGRLSILK--VCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLALQENGLD 710

  Fly   710 QVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYE 747
            ..         .:.::.|..|||.::.|::.:.|..||
Human   711 AT---------TVKQEHFLKSLKTVKPSLSCKDLALYE 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	15/86 (17%)
		P-loop_NTPase	482..>538	CDD:304359	24/57 (42%)
		AAA	515..652	CDD:214640	61/156 (39%)
		AAA	519..650	CDD:278434	58/150 (39%)
		Vps4_C	<722..754	CDD:286426	8/26 (31%)
SPATA5L1	NP_076968.2	CDC48	22..746	CDD:273521	170/623 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..203		8/26 (31%)
		AAA	237..367	CDD:278434	31/135 (23%)
		AAA	501..651	CDD:278434	58/149 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810