Protein Alignment spas and spata5l1

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001070056.2
• Gene: spata5l1 / 767648
• ZFINID: ZDB-GENE-060929-204
• Length: 748
• Species: Danio rerio
• Alignment Length: 682
• Identity: 169/682 - (24%)
• Similarity: 257/682 - (37%)
• Gaps: 224/682 - (32%)

  Fly   244 LKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFL 308
            ||:..:...||:...|   :.::||.|||.|                |:....:||..:..:..:
Zfish   100 LKVFVQRLEHKKRVSE---RSLQELLDGIYV----------------HEGHLVDLSGVKAEIRCV 145

  Fly   309 ALREQDLQMQRLSL-----------------KEKQKEEAQSKPQKTREPMLAG---MTNEPMKL- 352
            .:.:.:...||..|                 .::|:::..:.|....|.:.|.   |...|::.
Zfish   146 LVEKVNSGSQRAGLITARTCVDISTIQTVKHLDRQQQQVSAAPLGGMEDVFASLKEMITFPLRYP 210

  Fly   353 -RVRSSGYG-PKATTSAQPTASGRKLTI--------------------GSK-------------- 381
             .:|..|.. |:......|...|:.|.:                    ||:
Zfish   211 GSLRQLGLSCPRGLLLIGPPGVGKTLLVRCVAKDIGATLVTVNGPEVTGSRPGESEENLRRVFEQ 275

  Fly   382 -------RPVNLAVANKSQTLPRNLGSKTS------------------------VGAVQRQPAKT 415
                   .|..|.:.......||..||.::                        :||. .||
Zfish   276 ARDAADDGPCVLLIDEIDSLCPRRTGSSSAPENRLVAQLLTLMDAIGSHEGFVIIGAT-NQP--- 336

  Fly   416 AATPPAVRRQFSSGR-------NTPPQRSR----------TPINNN-----------GPSGS--- 449
            .:..||:||   .||       ..|....|          .|::.:           |..|:
Zfish   337 DSLDPALRR---PGRFDREVIIGVPSLLQRRSILKCVCREMPLSPDVDLNTLAEMTCGYVGADLS 398

  Fly   450 ----------------GASTPVVSVKGVEQKL--VQ--LILDEIVEGGA----KVEWTDIAGQDV 490
                            |||.| ||::...|.|  ||  .:...|   ||    .:.|..|.|.:.
Zfish   399 ALSREAALQAMRHSQMGASEP-VSMQHFMQALRHVQPSCLRSSI---GATDFKPIGWEQIGGLED 459

  Fly   491 AKQALQEMVILPSVRPELFT--GLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLT 553
            .|..|::.:..|...||.|.  |:..| :|:||:||||..||.|.:|.|:....:|.::|.|.|.
Zfish   460 VKLKLKQSIEWPMRFPEAFVRLGVSRP-RGVLLYGPPGCAKTTLVKAAASSSHCSFFSLSGAELF 523

  Fly   554 SKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSER---SSSEHEASRRLKTEFLVEFDG--- 612
            |.||||.||.:..|||.||...|||:|:|||||::..|   |||.|....::.:..|.|.||
Zfish   524 SPYVGDSEKTLAQLFAQARACAPSIVFLDEVDSMVGSREDGSSSSHSVQSQVLSVLLTELDGVGV 588

  Fly   613 --------------LPGNPDGD--------------RIVVLAATNRPQELDEAALR--RFTKRVY 647
                          |.|....|              .::::||||||:.||.|.||  |..:.:|
Zfish   589 RTLERRSTCRKIALLEGGDQEDVRLHQMELQEVCNKDVLIVAATNRPEALDSALLRPGRLDQIIY 653

  Fly   648 VSLPDEQTRELLLNRLLQKQGSPLDTE-ALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQV 711
            |..||.|.| |.:.|:..| ..||..: .|..||..|:.:||:||..|.|:|||..:||
Zfish   654 VPPPDLQAR-LAVLRICTK-SVPLHQDVCLEDLAAQTELFSGADLENLCKEAALLALRE------ 710

  Fly   712 KCLDISAMRAITEQDFHSSLKRIRRSVAPQSL 743
               |..|:..:.::.|..:|:.:..|::.:.|
Zfish   711 ---DGLAVSCVRQKYFLKALQMLSPSLSAEQL 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	14/63 (22%)
		P-loop_NTPase	482..>538	CDD:304359	22/57 (39%)
		AAA	515..652	CDD:214640	64/172 (37%)
		AAA	519..650	CDD:278434	62/166 (37%)
		Vps4_C	<722..754	CDD:286426	4/22 (18%)
spata5l1	NP_001070056.2	CDC48	13..740	CDD:273521	169/682 (25%)
		AAA	224..357	CDD:278434	21/139 (15%)
		AAA	489..655	CDD:278434	61/165 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900