Protein Alignment spas and Iqca

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001355651.1
• Gene: Iqca / 74918
• MGIID: 1922168
• Length: 838
• Species: Mus musculus
• Alignment Length: 711
• Identity: 152/711 - (21%)
• Similarity: 270/711 - (37%)
• Gaps: 238/711 - (33%)

  Fly   125 LFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNR-EGDG 188
            |||.:...|.|           |.:|   .:.||   |:.:::....|:..:|...:|.. ||..
Mouse   244 LFNEVSDAIVQ-----------SKQV---TNLRD---EVQLKHEQDYQEALVNIKEDLKMLEGPD 291

  Fly   189 QEQQLSNQPQRF----------RPIQPLEMAANRPGGG-------YSPGP--GDPLLAKQKHHHR 234
            .::.|.:|.:::          .|..|     |...||       .:|..  || ::|.|:...:
Mouse   292 IKEHLQDQIRQWFIECRNLTGTFPDYP-----NEEDGGSALIFSNKTPEQVMGD-IIATQEEEEK 350

  Fly   235 RAFEYISKALKIDEENEG---------HKELAIELYRKGIKE---------------LEDGIAV- 274
            ..    .|..|.|:||:|         .||..:.|..|.:|:               :|:|.::
Mouse   351 LK----KKKKKEDKENKGKKGKKEKKEKKEKKVSLKEKAMKDEDEEWKMSPSLFLQLMEEGNSLY 411

  Fly   275 -DCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTR 338
             |.|..:.:.|:..|                       :.|.::    :||::::|.:
Mouse   412 KDIWLNKDESWNFPQ-----------------------DYDPEL----IKEEKRKELE------- 442

  Fly   339 EPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKT 403
                       |::||:
Mouse   443 -----------MEIRVQ------------------------------------------------ 448

  Fly   404 SVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQK---- 464
             |..:.||..|....  ||.|:.    ..||::.:....|.|..|....      :|.::|
Mouse   449 -VDELMRQELKNLKL--AVNREM----EIPPRQKKGKKKNKGRKGRRGK------RGKKEKDLTA 500

  Fly   465 --LVQLILDEIVEGG-----AKVEWTDIAGQ------DVAKQALQEMVILPSVRPELFT--GL-- 512
              .::.:..|:||.|     .||..:|..|:      .:.:.|::.|..|..|| :|.|  |:
Mouse   501 DRTIESLYQELVEKGLLIQALKVNLSDYIGEYSYLGTTLRQVAIEPMPSLLDVR-QLITLYGILP 564

  Fly   513 --------RAP-AKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDG--EKLVRA 566
                    ||| .|.|||.||.|.||.:|..|:.||..|...|:||.::..||.|..  :.::..
Mouse   565 LGSAEVHERAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTGLQMMIHL 629

  Fly   567 LFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPG-----NPDGDRIVVLA 626
            :|.|||.:|||:::|.:.:....::..   :|.:|.:.:.|..:  ||.     .|| |||:::.
Mouse   630 VFKVARQLQPSVVWIQDTEKTFYKKVP---QAEKRFEPKRLKRY--LPKLLKLLKPD-DRILIVG 688

  Fly   627 ATNRPQELD-EAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALR--RLAKITDGYSG 688
            .|:||.:.: :...|.:.|.:.|..||..:|.:|...::.:.|..| |.:|.  .|:|:|||::.
Mouse   689 TTHRPFDAELQPFCRVYQKIILVPRPDYASRYVLWKEIILRNGGKL-TNSLNISCLSKVTDGFTQ 752

  Fly   689 SDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKW 749
            ..:..:.||...|  |.|..:        |.:.:|..:|.:.:..: ..|..:...|::.|
Mouse   753 GQIVQVIKDVLTE--RRLRQQ--------AHKPLTAIEFITMMTNM-NPVYREEEESFKNW 802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	17/103 (17%)
		P-loop_NTPase	482..>538	CDD:304359	24/74 (32%)
		AAA	515..652	CDD:214640	45/145 (31%)
		AAA	519..650	CDD:278434	43/138 (31%)
		Vps4_C	<722..754	CDD:286426	5/28 (18%)
Iqca	NP_001355651.1	SpoVK	<578..797	CDD:223540	66/236 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900