DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and Trip13

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_081458.1	Gene:	Trip13 / 69716	MGIID:	1916966	Length:	432	Species:	Mus musculus

Alignment Length:	317	Identity:	69/317 - (21%)
Similarity:	119/317 - (37%)	Gaps:	90/317 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 INNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEG----------GAKVE--WTDIAGQDVAKQ 493
            :|..|||...                   |||..|.          .|:..  |..:......|.
Mouse   102 LNEEGPSSEN-------------------LDEETENIIAASHWVLPAAEFHGLWDSLVYDVEVKS 147

  Fly   494 ALQEMVIL------PSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECS---------AT 543
            .|.:.|:.      .:|...|.|..|.    :||.||||.|||.|.:|:|.:.:         ..
Mouse   148 HLLDYVMTTVLFSDKNVDSNLITWNRV----VLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQ 208

  Fly   544 FLNISAASLTSKYVGDGEKLVRALFAVARHM---QPSIIF--IDEVDSLLSERSS----SEHEAS 599
            .:.|::.||.||:..:..|||..:|...:.:   :.:::|  ||||:||.:.|::    :|...:
Mouse   209 LIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKEALVFVLIDEVESLTAARNACRAGAEPSDA 273

  Fly   600 RRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQT--------- 655
            .|:....|.:.|.:..:   ..:|:|..:|..:::|.|.:.|...:.|:..|....
Mouse   274 IRVVNAVLTQIDQIKRH---SNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCL 335

  Fly   656 ------------------RELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTAL 694
                              |||.:...::...|.|.. .|..:::.::|.||..|..|
Mouse   336 EELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSL-LLSEISRKSEGLSGRVLRKL 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	19/61 (31%)
		AAA	515..652	CDD:214640	40/154 (26%)
		AAA	519..650	CDD:278434	40/148 (27%)
		Vps4_C	<722..754	CDD:286426
Trip13	NP_081458.1	AAA	172..322	CDD:214640	41/156 (26%)
Trip13	NP_081458.1	AAA	175..320	CDD:278434	40/147 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900