Protein Alignment spas and Afg2b

DIOPT Version :10

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001103117.1
• Gene: Afg2b / 691729
• RGDID: 1595990
• Length: 747
• Species: Rattus norvegicus
• Alignment Length: 640
• Identity: 172/640 - (26%)
• Similarity: 265/640 - (41%)
• Gaps: 124/640 - (19%)

  Fly   154 PHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAA---NRPGG 215
            ||.|       :..|.|...| :..|.|:...|..:......:..|.....||.:||   ..|.|
  Rat   173 PHTR-------ITLSDKPPPQ-VEPPGEVTLGGLSETADSLRELLRLPLCYPLALAALGLAVPRG 229

  Fly   216 GYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGR 280
            ....||  |.:.|.:.....|.|..::.|.:...       |::..|.|  |.|:.:.
  Rat   230 VLLAGP--PGVGKTQLVRAVAREAGAELLAVSAP-------ALQGTRPG--ETEENVR------- 276

  Fly   281 GDVWDRAQRLHDKMQTNLSMARDRLHFLALR--------EQDLQMQRLSLKEKQKEEAQSKPQKT 337
             .|:.|||.|..:..:.|.:  |.:..|..|        |..:..|.|:|.:....:
  Rat   277 -RVFQRAQELASRGPSLLFL--DEVDALCPRRGGPQRAPESRVVAQVLTLLDGIHGD-------- 330

  Fly   338 REPMLAGMTNEPMKL--RVRSSGYGPKATTSAQPTASGRKLTIG---SKRPVNLAVANKSQTLPR 397
            ||.::.|.||.|.:|  .:|..|...:......||...|:..:|   ||.|::..:
  Rat   331 REVVVVGATNRPDELDPALRRPGRFDREVIIGTPTLKQREAILGVITSKMPISSHI--------- 386

  Fly   398 NLGSKTS-----VGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSR---TPINNNGPSGSGASTP 454
            :||....     |||......:.|||...::.:  ..:|.|.....   .......||...:|..
  Rat   387 DLGLLAEMTVGYVGADLTALCREAATCALLKNE--KNQNNPKIEETDFLEAFKKVQPSSFRSSIG 449

  Fly   455 VVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFT--GLRAPAK 517
            :..::                   .|.|..|.|.:..|..|::.|..|...|:.|.  ||..| |
  Rat   450 LTDIR-------------------PVGWEQIGGLEDVKLKLKQCVEWPLKFPQEFARMGLTQP-K 494

  Fly   518 GLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFID 582
            ||||:||||..||.|.||:||.|..:|:::..|.|.|.:|||.||::..:|..||...|:::|:|
  Rat   495 GLLLYGPPGCAKTTLVRALATSCHCSFVSVCGADLFSPFVGDSEKVLSQVFRQARANTPALVFLD 559

  Fly   583 EVDSLLSERS--SSEHEASRRLKTEFLVEFDGL-------PGNPDGDR---------IVVLAATN 629
            |:||:|..||  ||..:|..|:.:..|.|.||:       .|:....:         ::::.|||
  Rat   560 EIDSVLGSRSVGSSGCDARERVLSVLLNELDGVGVRTVERRGSKASQQECQEILSRSVMIVVATN 624

  Fly   630 RPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLT 692
            ||..||:|.||  |..|.|||..||.:.|..:|..........|:. :|..||..|..:||:||.
  Rat   625 RPDVLDDALLRPGRLDKMVYVPPPDREGRLSILKVCTNNMPIGLNV-SLENLAAETCYFSGADLR 688

  Fly   693 ALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYE 747
            .|.|:|||..::|..:|..         .:.::.|..:||.::.|:..:.|..||
  Rat   689 NLCKEAALFALQENGLEAT---------TVEQEHFTEALKTVKPSLTLKDLTFYE 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	15/77 (19%)
		RecA-like_spastin	484..648	CDD:410932	71/185 (38%)
		AAA_lid_3	676..727	CDD:465537	15/50 (30%)
		Vps4_C	<722..754	CDD:462762	7/26 (27%)
Afg2b	NP_001103117.1	CDC48	14..738	CDD:273521	172/640 (27%)