Protein Alignment spas and Spata5l1

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001103117.1
• Gene: Spata5l1 / 691729
• RGDID: 1595990
• Length: 747
• Species: Rattus norvegicus
• Alignment Length: 640
• Identity: 172/640 - (26%)
• Similarity: 265/640 - (41%)
• Gaps: 124/640 - (19%)

  Fly   154 PHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAA---NRPGG 215
            ||.|       :..|.|...| :..|.|:...|..:......:..|.....||.:||   ..|.|
  Rat   173 PHTR-------ITLSDKPPPQ-VEPPGEVTLGGLSETADSLRELLRLPLCYPLALAALGLAVPRG 229

  Fly   216 GYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGR 280
            ....||  |.:.|.:.....|.|..::.|.:...       |::..|.|  |.|:.:.
  Rat   230 VLLAGP--PGVGKTQLVRAVAREAGAELLAVSAP-------ALQGTRPG--ETEENVR------- 276

  Fly   281 GDVWDRAQRLHDKMQTNLSMARDRLHFLALR--------EQDLQMQRLSLKEKQKEEAQSKPQKT 337
             .|:.|||.|..:..:.|.:  |.:..|..|        |..:..|.|:|.:....:
  Rat   277 -RVFQRAQELASRGPSLLFL--DEVDALCPRRGGPQRAPESRVVAQVLTLLDGIHGD-------- 330

  Fly   338 REPMLAGMTNEPMKL--RVRSSGYGPKATTSAQPTASGRKLTIG---SKRPVNLAVANKSQTLPR 397
            ||.::.|.||.|.:|  .:|..|...:......||...|:..:|   ||.|::..:
  Rat   331 REVVVVGATNRPDELDPALRRPGRFDREVIIGTPTLKQREAILGVITSKMPISSHI--------- 386

  Fly   398 NLGSKTS-----VGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSR---TPINNNGPSGSGASTP 454
            :||....     |||......:.|||...::.:  ..:|.|.....   .......||...:|..
  Rat   387 DLGLLAEMTVGYVGADLTALCREAATCALLKNE--KNQNNPKIEETDFLEAFKKVQPSSFRSSIG 449

  Fly   455 VVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFT--GLRAPAK 517
            :..::                   .|.|..|.|.:..|..|::.|..|...|:.|.  ||..| |
  Rat   450 LTDIR-------------------PVGWEQIGGLEDVKLKLKQCVEWPLKFPQEFARMGLTQP-K 494

  Fly   518 GLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFID 582
            ||||:||||..||.|.||:||.|..:|:::..|.|.|.:|||.||::..:|..||...|:::|:|
  Rat   495 GLLLYGPPGCAKTTLVRALATSCHCSFVSVCGADLFSPFVGDSEKVLSQVFRQARANTPALVFLD 559

  Fly   583 EVDSLLSERS--SSEHEASRRLKTEFLVEFDGL-------PGNPDGDR---------IVVLAATN 629
            |:||:|..||  ||..:|..|:.:..|.|.||:       .|:....:         ::::.|||
  Rat   560 EIDSVLGSRSVGSSGCDARERVLSVLLNELDGVGVRTVERRGSKASQQECQEILSRSVMIVVATN 624

  Fly   630 RPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLT 692
            ||..||:|.||  |..|.|||..||.:.|..:|..........|:. :|..||..|..:||:||.
  Rat   625 RPDVLDDALLRPGRLDKMVYVPPPDREGRLSILKVCTNNMPIGLNV-SLENLAAETCYFSGADLR 688

  Fly   693 ALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYE 747
            .|.|:|||..::|..:|..         .:.::.|..:||.::.|:..:.|..||
  Rat   689 NLCKEAALFALQENGLEAT---------TVEQEHFTEALKTVKPSLTLKDLTFYE 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	15/77 (19%)
		P-loop_NTPase	482..>538	CDD:304359	26/57 (46%)
		AAA	515..652	CDD:214640	63/156 (40%)
		AAA	519..650	CDD:278434	60/150 (40%)
		Vps4_C	<722..754	CDD:286426	7/26 (27%)
Spata5l1	NP_001103117.1	CDC48	14..738	CDD:273521	172/640 (27%)
		AAA	230..362	CDD:278434	34/160 (21%)
		AAA	496..646	CDD:278434	59/149 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900