Protein Alignment spas and Nvl

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_080447.1
• Gene: Nvl / 67459
• MGIID: 1914709
• Length: 855
• Species: Mus musculus
• Alignment Length: 665
• Identity: 168/665 - (25%)
• Similarity: 276/665 - (41%)
• Gaps: 130/665 - (19%)

  Fly   158 DCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLS---------NQP---QRFRPIQPLEMAA 210
            |..||.::|..:|.:...|...:....:..|.:..|.         ..|   |....:.|..:..
Mouse   238 DGEIEALLQKKAKARSTELQISNVKFEDVGGNDATLKEVCKMLIHMRHPEVYQHLGVVPPRGVLL 302

  Fly   211 NRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVD 275
            :.|     ||.|..|||     |..|                 .||.:.:.:....|:..|::
Mouse   303 HGP-----PGCGKTLLA-----HAIA-----------------GELDLPILKVAAPEIVSGVS-- 338

  Fly   276 CWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEE---AQ------ 331
                 |:...:.:.|.|:..:|...      .:.:.|.|....:..:..|..|.   ||
Mouse   339 -----GESEQKLRELFDQAVSNAPC------IVFIDEIDAITPKREVASKDMERRIVAQLLTCMD 392

  Fly   332 --SKPQKTREPMLAGMTNEPMKL--RVRSSGYGPKATTSAQPTASGRKLTIGS-----KRPVNLA 387
              :....|...::.|.||.|..|  .:|.:|...:......|..:.|:..:.:     :.|....
Mouse   393 DLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREVCLGIPDEAARERILQTLCRKLRLPETFN 457

  Fly   388 VANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGAS 452
            ..:.:...|..:|:  .:.|:.|:.|..|.....:::|  :.:...|:....|...:.....||.
Mouse   458 FCHLAHLTPGFVGA--DLMALCREAAMCAVNRVLMKQQ--AQQKKKPEIEGLPSEGDQEERLGAE 518

  Fly   453 TPVVSVKGVEQKLVQLILDE-----------------------IVEGGAK---------VEWTDI 485
             |....:...|:|:.|:.|:                       .|:..||         |.|.||
Mouse   519 -PTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALAEVQPSAKREGFVTVPNVTWADI 582

  Fly   486 -AGQDVAKQALQEMVILPSVR-PELF--TGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLN 546
             |.:|:..:.:  |.||..|| |:.|  .||..|| |:||.||||.||||||:|||.|....|::
Mouse   583 GALEDIRDELI--MAILAPVRNPDQFRTLGLGTPA-GILLAGPPGCGKTLLAKAVANESGLNFIS 644

  Fly   547 ISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFD 611
            :....|.:.|||:.|:.||.:|..|::..|.:||.||||:|...||..|..||.|:..:.|.|.|
Mouse   645 VKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMD 709

  Fly   612 GLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGS--PLD 672
            ||...   .::.:|||||||..:|.|.||  |..|.::|.||....|..:| :.:.|.|:  |||
Mouse   710 GLETR---QQVFILAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRVAIL-KTITKNGTKPPLD 770

  Fly   673 TEALRRLAKITDG-----YSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLK 732
            .:.  .|..|.:.     |:|:|||||.::|:|..:|:....|...:....:: ::.:.|..:.|
Mouse   771 EDV--NLETIANDLRCNCYTGADLTALVREASLCALRQEITAQKNGVGAGELK-VSHKHFEDAFK 832

  Fly   733 RIRRSVAPQSLNSYE 747
            :::.|::.:....||
Mouse   833 KVKPSISIKDQVMYE 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	10/77 (13%)
		P-loop_NTPase	482..>538	CDD:304359	31/59 (53%)
		AAA	515..652	CDD:214640	63/138 (46%)
		AAA	519..650	CDD:278434	59/132 (45%)
		Vps4_C	<722..754	CDD:286426	5/26 (19%)
Nvl	NP_080447.1	Interaction with RPL5. /evidence=ECO:0000250|UniProtKB:O15381	1..219
		Nucleolin_bd	2..72	CDD:293330
		Nucleolar localization signal. /evidence=ECO:0000269|PubMed:21474449	49..52
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	83..234
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381	85..88
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381	217..231
		Interaction with WDR74. /evidence=ECO:0000250|UniProtKB:O15381	266..473		41/248 (17%)
		SpoVK	283..842	CDD:223540	158/613 (26%)
		AAA	300..432	CDD:278434	31/171 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..523		5/27 (19%)
		AAA	617..747	CDD:278434	59/132 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900