DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and SPG7

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001350779.1	Gene:	SPG7 / 6687	HGNCID:	11237	Length:	809	Species:	Homo sapiens

Alignment Length:	287	Identity:	104/287 - (36%)
Similarity:	151/287 - (52%)	Gaps:	36/287 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   473 IVEG--GAKVEWTDIAGQDVAKQALQEMV-ILPSVRPELF--TGLRAPAKGLLLFGPPGNGKTLL 532
            ||:|  |..|.:.|:||...||..::|.| .|.|  ||.|  .|.:.| ||.||.||||.|||||
Human   297 IVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKS--PERFLQLGAKVP-KGALLLGPPGCGKTLL 358

  Fly   533 ARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSS---- 593
            |:|||||....||.::.........|.|...||:||..||...|.|::|||:|::..:||:
Human   359 AKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSG 423

  Fly   594 -SEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPD-EQ 654
             |..|..:.| .:.|||.||:...   |.::|||:|||...||.|.:|  |..:.|::.||. ::
Human   424 FSNTEEEQTL-NQLLVEMDGMGTT---DHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484

  Fly   655 TRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRE-------LN----V 708
            .||:....|...:.:...|...:|||::|.|:||:|:..:..:|||...||       ||    |
Human   485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLNFEYAV 549

  Fly   709 EQVKCLDISAMRAITEQD-----FHSS 730
            |:|........:.:::::     ||.|
Human   550 ERVLAGTAKKSKILSKEEQKVVAFHES 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	30/58 (52%)
		AAA	515..652	CDD:214640	60/143 (42%)
		AAA	519..650	CDD:278434	56/137 (41%)
		Vps4_C	<722..754	CDD:286426	3/14 (21%)
SPG7	NP_001350779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..133
		FtsH_ext	145..242	CDD:310823
		TIP49	265..729	CDD:332389	104/287 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910