DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and katnal2

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001032491.1	Gene:	katnal2 / 641431	ZFINID:	ZDB-GENE-051113-156	Length:	485	Species:	Danio rerio

Alignment Length:	374	Identity:	134/374 - (35%)
Similarity:	185/374 - (49%)	Gaps:	83/374 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 PKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVR-- 423
            ||.|.........|::....||         |.||||       :.::||..::........:
Zfish    87 PKLTKKLAEQGESRRIKSCGKR---------SHTLPR-------INSIQRPSSRNTVKKSESKLT 135

  Fly   424 -RQFSS---------------GRNTPPQRSRTPINNNGPSGS----------------GAST--- 453
             |.||.               |.|..|     .|.|....|:                ||:.
Zfish   136 GRDFSKSSDGDRLTSADTLGFGLNVSP-----IIRNGAEEGTHMRKIDYRNLIQDAVRGAANDTL 195

  Fly   454 -------------PVVSVKGVE---QKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILP 502
                         ||.::.|:.   ::|..:|..:|......|.|.||.|.:.||:.::|.|:.|
Zfish   196 HNADFTEQERLLKPVSALIGMNSDMKELAAVISRDIYLHNPNVRWDDIIGLEAAKRLVKEAVVYP 260

  Fly   503 SVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRAL 567
            ...|:||||:.:|.|||||:||||.|||:||:||||||:.||.||||:|:.||:.||.|||||.|
Zfish   261 IKYPQLFTGILSPWKGLLLYGPPGTGKTMLAKAVATECNTTFFNISASSIVSKWRGDSEKLVRVL 325

  Fly   568 FAVARHMQPSIIFIDEVDSLLSER---SSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATN 629
            |.:||:..||.||:||::|::|:|   ...:||.|||:|||.||:.|||..:  .|.:.||||:|
Zfish   326 FELARYHAPSTIFLDELESVMSQRGVGQGGDHEGSRRMKTELLVQMDGLARS--NDLVFVLAASN 388

  Fly   630 RPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLL----QKQGSPLDTE 674
            .|.|||.|.|||..||:.||||....|:.:::..|    ...|..|.||
Zfish   389 LPWELDHAMLRRLEKRILVSLPSAPARQAMISHWLPPVSNTGGVELRTE 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	31/55 (56%)
		AAA	515..652	CDD:214640	82/139 (59%)
		AAA	519..650	CDD:278434	77/133 (58%)
		Vps4_C	<722..754	CDD:286426
katnal2	NP_001032491.1	LisH	25..55	CDD:128913
		P-loop_NTPase	242..>296	CDD:304359	30/53 (57%)
		AAA	273..410	CDD:214640	81/138 (59%)
		AAA	277..409	CDD:278434	77/133 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910