DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and FIGNL1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001036227.1	Gene:	FIGNL1 / 63979	HGNCID:	13286	Length:	674	Species:	Homo sapiens

Alignment Length:	404	Identity:	170/404 - (42%)
Similarity:	251/404 - (62%)	Gaps:	26/404 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 GPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRR 424
            |||..:|. ||....|        ..|.|..:.:.......|.:|.|.|::...       |.|.
Human   285 GPKEDSSL-PTFKTAK--------EQLWVDQQKKYHQPQRASGSSYGGVKKSLG-------ASRS 333

  Fly   425 QFSSGRNTPPQRSRTPINNNG-----PSGSGASTPVVSV----KGVEQKLVQLILDEIVEGGAKV 480
            :...|:..||...:.....||     |.|:|.:.|...|    |.:|.|:::||::||::.|..|
Human   334 RGILGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDERLKNLEPKMIELIMNEIMDHGPPV 398

  Fly   481 EWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFL 545
            .|.||||.:.||..::|:|:.|.:||::|||||.|.||:|||||||.||||:.:.:|::..|||.
Human   399 NWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFF 463

  Fly   546 NISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEF 610
            :|||:|||||:||:|||:|||||||||..||::|||||:|||||:|...|||:|||:||||||:.
Human   464 SISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQL 528

  Fly   611 DGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEA 675
            ||...:.: |||:|:.|||||||:||||.||..||:|:.||:...|:.::..|:.|:...|..|.
Human   529 DGATTSSE-DRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIVINLMSKEQCCLSEEE 592

  Fly   676 LRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAP 740
            :.::.:.:|.:||:|:|.|.::|:|.|||.|....:..:....:|.|...||.::.:.:|.||:|
Human   593 IEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPDQVRPIAYIDFENAFRTVRPSVSP 657

  Fly   741 QSLNSYEKWSQDYG 754
            :.|..||.|::.:|
Human   658 KDLELYENWNKTFG 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	31/55 (56%)
		AAA	515..652	CDD:214640	88/136 (65%)
		AAA	519..650	CDD:278434	84/130 (65%)
		Vps4_C	<722..754	CDD:286426	11/31 (35%)
FIGNL1	NP_001036227.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..179
		Necessary and sufficient for interaction with RAD51. /evidence=ECO:0000305\|PubMed:23754376	295..344		11/63 (17%)
		SpoVK	<374..668	CDD:223540	144/294 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820