DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and Fignl1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_011242039.1	Gene:	Fignl1 / 60530	MGIID:	1890648	Length:	692	Species:	Mus musculus

Alignment Length:	357	Identity:	159/357 - (44%)
Similarity:	238/357 - (66%)	Gaps:	14/357 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   402 KTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPV----VSVKGVE 462
            |.|:||.:.:.......||...:|..|.::....:|         |.:|::.|.    ..:|.||
Mouse   343 KKSLGAGRSRGIFGKFVPPVSNKQDGSEQHAKKHKS---------SRAGSAEPAHLTDDCLKNVE 398

  Fly   463 QKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGN 527
            .::|:||::||::.|..|.|.||||.:.||..::|:|:.|.:||::|||||.|.||:|||||||.
Mouse   399 PRMVELIMNEIMDHGPPVHWDDIAGVEFAKATIKEIVVWPMMRPDIFTGLRGPPKGILLFGPPGT 463

  Fly   528 GKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERS 592
            ||||:.:.:|::..|||.:|||:|||||:||:|||:|||||||||..||::|||||:|||||:|.
Mouse   464 GKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRG 528

  Fly   593 SSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRE 657
            ..|||:|||:||||||:.||...:.: |||:|:.|||||||:||||.||..||:|:.||:...|:
Mouse   529 DGEHESSRRIKTEFLVQLDGATTSSE-DRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARK 592

  Fly   658 LLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAI 722
            .::..|:.|:...|..|....:.:.:||:||:|:|.|.::|:|.|||.|:...:..:....:|.|
Mouse   593 QIVGNLMSKEQCCLSDEETDLVVQQSDGFSGADMTQLCREASLGPIRSLHAADIATISPDQVRPI 657

  Fly   723 TEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
            ...||.::.|.:|.:|:|:.|..||.|::.:|
Mouse   658 AYIDFENAFKTVRPTVSPKDLELYENWNETFG 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	31/55 (56%)
		AAA	515..652	CDD:214640	88/136 (65%)
		AAA	519..650	CDD:278434	84/130 (65%)
		Vps4_C	<722..754	CDD:286426	11/31 (35%)
Fignl1	XP_011242039.1	RecA-like_Figl-1	398..583	CDD:410933	111/185 (60%)
		AAA_lid_3	608..>639	CDD:407720	11/30 (37%)
		Vps4_C	<649..689	CDD:401324	12/39 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720