DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and Fign

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_068362.1	Gene:	Fign / 60344	MGIID:	1890647	Length:	759	Species:	Mus musculus

Alignment Length:	805	Identity:	198/805 - (24%)
Similarity:	314/805 - (39%)	Gaps:	236/805 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SSSSASSSSTKSPIKSSSGAGSSGGGLGGRQSTHRSSSASNVAAVVAGGSSAAGGGSSSNRRSPG 73
            ::|.|..||...|:..|:..|||.|..........|||......|     .:...|..|...:||
Mouse   129 TASKAGVSSALPPVDVSASIGSSPGVASNLTEPSYSSSTCGSHTV-----PSLHAGLPSQEYAPG 188

  Fly    74 SSPDGDD-DTTTTDDLTPTTCSPRSGHHHSYG----------------GYSSSVHKQNLYVVSFP 121
            .  :|.. .:|.:...||...||.....||.|                ||:.:   .||...|:|
Mouse   189 Y--NGSYLHSTYSSQATPALPSPHPSPLHSSGLLQPPPPPPPPPALVPGYNGT---SNLSSYSYP 248

  Fly   122 IIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNREG 186
                                                                 |.::|
Mouse   249 -----------------------------------------------------SASYP------- 253

  Fly   187 DGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDE--- 248
                      ||            ...|.|||||...|          ....|:...:....
Mouse   254 ----------PQ------------TAVGSGYSPGGAPP----------PPSAYLPSGIPAPTPLP 286

  Fly   249 -------ENEGH-----------KELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQ 295
                   ..:||           ...|..|.||..          ..:|:||:        |...
Mouse   287 PTTVPGYTYQGHGLTPIAPSALTNNSASSLKRKAF----------YMAGQGDM--------DSSY 333

  Fly   296 TNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYG 360
            .|.|..:.|                               .|:.||.. |.:..:....|.:|:.
Mouse   334 GNYSYGQQR-------------------------------STQSPMYR-MPDNSISNSNRGNGFD 366

  Fly   361 PKATTSA---------QPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTA 416
            ..|.||:         .|:...||.:..|.|.:         |.|....:|.|:|:
Mouse   367 RNAETSSLAFKPTKQLMPSEQQRKFSSQSSRAL---------TPPSYSTAKNSLGS--------- 413

  Fly   417 ATPPAVRRQFSSGRNTPPQRSR----------TPINNNGPSGSGASTPVV--SVKGVEQKLVQLI 469
                  |...|.|:.|.|..|.          .||...|...:.:|...|  .:|..:..|:.|:
Mouse   414 ------RSSESFGKYTSPVMSEHGDDHRQLLAHPIQGPGLRAATSSNHSVDEQLKNTDTHLIDLV 472

  Fly   470 LDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLAR 534
            .:||:..|..|:|:||||.|:.|..::|.|:.|.:|.:.|:||.|..:.:|||||.|.|||||.|
Mouse   473 TNEIITQGPPVDWSDIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGR 537

  Fly   535 AVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEAS 599
            .:|::..|||..|:.:.|.:|::|:.||::.|.|.|||..|||:||:.::|.|||.:.|.||...
Mouse   538 CIASQLGATFFKIAGSGLVAKWIGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVSEEHSPV 602

  Fly   600 RRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLL 664
            .|::||||::.|.:..:.: |:|||:.||::|:|:||:..|.|.||:.:.|||...|..::.:||
Mouse   603 SRMRTEFLMQLDTVLTSAE-DQIVVICATSKPEEIDESLRRYFMKRLLIPLPDSTARHQIIVQLL 666

  Fly   665 QKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHS 729
            .:....|:.:....|.:.|:|:||.|:..|.::||:.|:..:....:..:..|.:|.:|.|||.:
Mouse   667 TQHNYCLNDKEFALLVQRTEGFSGLDVAHLCQEAAVGPLHAMPATDLSAIMPSQLRPVTYQDFEN 731

  Fly   730 SLKRIRRSVAPQSLNSYEKWSQDYG 754
            :..:|:.|::.:.|:.|.:|::.:|
Mouse   732 AFCKIQPSISQKELDMYVEWNKMFG 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	14/98 (14%)
		P-loop_NTPase	482..>538	CDD:304359	27/55 (49%)
		AAA	515..652	CDD:214640	60/136 (44%)
		AAA	519..650	CDD:278434	59/130 (45%)
		Vps4_C	<722..754	CDD:286426	9/31 (29%)
Fign	NP_068362.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..237		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..293		8/44 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..429		26/147 (18%)
		26Sp45	389..736	CDD:130309	124/371 (33%)
		AAA	522..652	CDD:278434	59/130 (45%)
		Vps4_C	<723..756	CDD:286426	9/32 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810