DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and Spata5

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001156983.1	Gene:	Spata5 / 57815	MGIID:	1927170	Length:	893	Species:	Mus musculus

Alignment Length:	460	Identity:	148/460 - (32%)
Similarity:	210/460 - (45%)	Gaps:	79/460 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 QMQRLSLKEKQKEEAQS---KPQKTREPMLAG-----MTNEPMKLRVRSSGYGPKATTSAQPTAS 372
            |:.:|.|||.|...:||   ||...|....||     :|..|..    .||.|.:.:|
Mouse   233 QLSQLDLKEPQSPSSQSTPCKPTNDRTVNKAGEVLLDVTQSPRD----GSGLGLEEST------- 286

  Fly   373 GRKLTIGSKRPVNLAVANKSQTL-PRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQR 436
            |.|.:..|.:..|....::.:.| |.:.|:|::....                .|.|
Mouse   287 GLKCSFDSSKEGNTQPVSEEKLLKPASAGTKSNTDTF----------------YFIS-------- 327

  Fly   437 SRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVIL 501
            |.|.||          ...:.....||           :...||.:..|.|.:...:|::|::.|
Mouse   328 STTRIN----------LRKICTNSKEQ-----------DSQFKVTYDMIGGLNSQLKAIREIIEL 371

  Fly   502 PSVRPELFTGLRAPA-KGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVR 565
            |..:||||.....|| :||||:||||.|||::|||||.|..|....|:...:.||:.|:.|..:|
Mouse   372 PLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLR 436

  Fly   566 ALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNR 630
            .:||.|....||||||||:|:|..:|..::.|..:|:....|...||:.......|::||.||||
Mouse   437 QIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEGRVLVLGATNR 501

  Fly   631 PQELDEAALR---RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLT 692
            ||.|| ||||   ||.|.:.:.:|:.|.|..:|.:||::....|....|.|||....||.|:||.
Mouse   502 PQALD-AALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLANNAHGYVGADLK 565

  Fly   693 ALAKDAALEPIRELNVEQVKCLD--ISAMRAITEQDFHSSLKRIR----RSVAPQSLNSYEKWSQ 751
            ||..:|.|..:|.:..:|....|  ::.|..||..||...:..||    |.||....|  ..||
Mouse   566 ALCNEAGLHALRRVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMREVAIDVPN--VSWS- 627

  Fly   752 DYGDI 756
            |.|.:
Mouse   628 DIGGL 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	27/56 (48%)
		AAA	515..652	CDD:214640	63/140 (45%)
		AAA	519..650	CDD:278434	60/133 (45%)
		Vps4_C	<722..754	CDD:286426	13/35 (37%)
Spata5	NP_001156983.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		CDC48_N	64..132	CDD:304500
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..227
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..315		23/86 (27%)
		SpoVK	370..882	CDD:223540	107/267 (40%)
		AAA	390..522	CDD:278434	60/132 (45%)
		AAA	664..796	CDD:278434
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810