Protein Alignment spas and PSMC6

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_002797.4
• Gene: PSMC6 / 5706
• HGNCID: 9553
• Length: 389
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 125/512 - (24%)
• Similarity: 213/512 - (41%)
• Gaps: 147/512 - (28%)

  Fly   254 KELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQ 318
            ::.|::.|||.:.|                       |.::...|...|::|..|..:.:..:..
Human     5 RDKALQDYRKKLLE-----------------------HKEIDGRLKELREQLKELTKQYEKSEND 46

  Fly   319 RLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRP 383
            ..:|:...:...:...|.|.|..:...||            ||:.....:......||..|::..
Human    47 LKALQSVGQIVGEVLKQLTEEKFIVKATN------------GPRYVVGCRRQLDKSKLKPGTRVA 99

  Fly   384 VNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSG 448
            :::......:.|||.:.
Human   100 LDMTTLTIMRYLPREVD------------------------------------------------ 116

  Fly   449 SGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELF--TG 511
                              .|:.:...|....|.:::|.|.....:.|:|::.||...||||  .|
Human   117 ------------------PLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVG 163

  Fly   512 LRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQP 576
            : .|.||.||:||||.||||||||||::....||.:.::|:..||:|:..:|:|.:|..||..||
Human   164 I-IPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQP 227

  Fly   577 SIIFIDEVDSL----LSERSSSEHEASRRLKTEFLVEFDGLPGNPDGD---RIVVLAATNRPQEL 634
            .|||:||:|::    .||.:|::.|..|.| .|.|.:.||.      |   |:.::.|||||..|
Human   228 CIIFMDEIDAIGGRRFSEGTSADREIQRTL-MELLNQMDGF------DTLHRVKMIMATNRPDTL 285

  Fly   635 DEAALR--RFTKRVYVSLPDEQTRELLLN---RLLQKQGSPLDTEALRRLAKITDGYSGSDLTAL 694
            |.|.||  |..:::::.||:||.|..:|.   ..:.|.|. :|.||   :.|::||::|:||..:
Human   286 DPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGE-IDYEA---IVKLSDGFNGADLRNV 346

  Fly   695 AKDAALEPIRELNVEQVKCLDISAMRA----ITEQDFHSSLKRIRRSVAPQSLNSYE 747
            ..:|.:                .|:||    :.::||..:::::..|...:|...|:
Human   347 CTEAGM----------------FAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYK 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	9/53 (17%)
		P-loop_NTPase	482..>538	CDD:304359	29/57 (51%)
		AAA	515..652	CDD:214640	62/145 (43%)
		AAA	519..650	CDD:278434	58/139 (42%)
		Vps4_C	<722..754	CDD:286426	5/26 (19%)
PSMC6	NP_002797.4	RPT1	4..387	CDD:224143	124/510 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910